中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2008年
8期
1051-1053
,共3页
戴列军%谢玉桃%谭德明%熊清芳%陈海鸥%侯环荣
戴列軍%謝玉桃%譚德明%熊清芳%陳海鷗%侯環榮
대렬군%사옥도%담덕명%웅청방%진해구%후배영
肝炎,丙型,慢性%B淋巴细胞%肿瘤坏死因子α%基因表达
肝炎,丙型,慢性%B淋巴細胞%腫瘤壞死因子α%基因錶達
간염,병형,만성%B림파세포%종류배사인자α%기인표체
Hepatits C,chronic%B-lymphocytes%Tumor necrosis factor-alpha%Gene expression
目的 研究慢性丙型肝炎患者血清BlyS因子水平及其临床意义.方法 采用ELISA法检测58例慢性丙肝患者的血清BLyS水平,并与40例健康对照组比较,检测慢性丙肝患者的检测类风湿因子、肝纤维化血清学指标、以及免疫球蛋白水平,分析他们与BLyS表达水平之间的关系.结果 慢性丙肝患者的平均血清BLys水平高于健康对照组[(4.7±1.1)ng/ml VS(3.1±0.67)ng/ml,P＜0.01)]慢性丙肝患者中类风湿因子阳性者高于类风湿因子阴性[(5.4±0.98)ng/ml VS(4.4 ±1.0)ng/ml,P＜0.01)].BLyS水平与肝纤维化血清学指标透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)有一定的相关性,而与免疫球蛋白(IgG,IgM,IgA),谷丙转氨酶(ALT),HCV-RNA无相关性.结论 慢性丙肝患者存在BLyS过度表达,BLyS可能与慢性丙肝的自身免疫现象以及肝纤维化程度有一定的关系.
目的 研究慢性丙型肝炎患者血清BlyS因子水平及其臨床意義.方法 採用ELISA法檢測58例慢性丙肝患者的血清BLyS水平,併與40例健康對照組比較,檢測慢性丙肝患者的檢測類風濕因子、肝纖維化血清學指標、以及免疫毬蛋白水平,分析他們與BLyS錶達水平之間的關繫.結果 慢性丙肝患者的平均血清BLys水平高于健康對照組[(4.7±1.1)ng/ml VS(3.1±0.67)ng/ml,P＜0.01)]慢性丙肝患者中類風濕因子暘性者高于類風濕因子陰性[(5.4±0.98)ng/ml VS(4.4 ±1.0)ng/ml,P＜0.01)].BLyS水平與肝纖維化血清學指標透明質痠(HA)、層黏連蛋白(LN)、Ⅲ型前膠原(PCⅢ)、Ⅳ型膠原(Ⅳ-C)有一定的相關性,而與免疫毬蛋白(IgG,IgM,IgA),穀丙轉氨酶(ALT),HCV-RNA無相關性.結論 慢性丙肝患者存在BLyS過度錶達,BLyS可能與慢性丙肝的自身免疫現象以及肝纖維化程度有一定的關繫.
목적 연구만성병형간염환자혈청BlyS인자수평급기림상의의.방법 채용ELISA법검측58례만성병간환자적혈청BLyS수평,병여40례건강대조조비교,검측만성병간환자적검측류풍습인자、간섬유화혈청학지표、이급면역구단백수평,분석타문여BLyS표체수평지간적관계.결과 만성병간환자적평균혈청BLys수평고우건강대조조[(4.7±1.1)ng/ml VS(3.1±0.67)ng/ml,P＜0.01)]만성병간환자중류풍습인자양성자고우류풍습인자음성[(5.4±0.98)ng/ml VS(4.4 ±1.0)ng/ml,P＜0.01)].BLyS수평여간섬유화혈청학지표투명질산(HA)、층점련단백(LN)、Ⅲ형전효원(PCⅢ)、Ⅳ형효원(Ⅳ-C)유일정적상관성,이여면역구단백(IgG,IgM,IgA),곡병전안매(ALT),HCV-RNA무상관성.결론 만성병간환자존재BLyS과도표체,BLyS가능여만성병간적자신면역현상이급간섬유화정도유일정적관계.
Objectives To investigate the significance of serum BlyS level in HCV infected patients.Method Serum BlyS levels among 58 HCV infected patients were assayed with ELISA method,and compared with healthy control group(35 individuals).The relationship between serum Blys levels and general clinical data(RF,ALT,HCV-RNA,IgG,IgA,IgM,HA,C-Ⅳ,PCⅢ,LN)were analyzed.Resuits:Mean serum BlyS Was increased in patients with HCV infection(4.7±1.1)ng/ml compared with that(31 ±0.67)ns/ml in healthy controls(P＜0.01).BlyS levels were increased in HCV patients with positive RF compared with those with negative BF(5.4±0.98)ng/ml vs(4.4±1.0)ng/ml(P＜0.01).The senlm level of BlyS was found to be correlated with HA,C-Ⅳ,PC Ⅲ,LN rather than ALT,HCV-RNA,IgG,IgA and IgM.Conclusion BlyS may play a role in HCV associated autoimmtmity and liver cirrhosis.
