CAJ | 학술논문

目的探讨年龄、血压和新生儿体重以及实验室指标等多种因素与先兆子痫患者视网膜病变严重程度的相关性.方法回顾性研究2007年1月至2009年5月期间足月分娩的产妇,78例先兆子痫患者作为研究组,78例妊娠高血压(pregnancy-induced hypertension,PIH)患者作为对照组.待分析变量包括视网膜病变等级、年龄、血压、新生儿体重和各种实验室指标.采用Spearman等级相关分析联合有序结果变量回归分析,综合判断多种因素与视网膜病变严重程度的相关性,P<0.05视为具有统计学意义.结果先兆子痫患者视网膜病变的严重程度与新生儿体重呈负相关(β=-0.001,P=0.000),与血清尿酸水平呈正相关(β= 0.014,P=0.000).结论先兆子痫患者视网膜病变的严重程度与胎盘机能不全和胎儿宫内发育迟缓之间,具有直接相关性.
목적 탐토년령、혈압화신생인체중이급실험실지표등다충인소여선조자간환자시망막병변엄중정도적상관성.방법 회고성연구2007년1월지2009년5월기간족월분면적산부,78례선조자간환자작위연구조,78례임신고혈압(pregnancy-induced hypertension,PIH)환자작위대조조.대분석변량포괄시망막병변등급、년령、혈압、신생인체중화각충실험실지표.채용Spearman등급상관분석연합유서결과변량회귀분석,종합판단다충인소여시망막병변엄중정도적상관성,P<0.05시위구유통계학의의.결과 선조자간환자시망막병변적엄중정도여신생인체중정부상관(β=-0.001,P=0.000),여혈청뇨산수평정정상관(β= 0.014,P=0.000).결론 선조자간환자시망막병변적엄중정도여태반궤능불전화태인궁내발육지완지간,구유직접상관성.
Objective To discuss the association between severity of retinopathy and various clinical and laboratory manifestations in the patients with preeclampsia.Methods Medical records of 78 patients with preeclampsia and 78 patients with pregnancy-induced hypertension( PIH) were reviewed.Parameters analyzed were retinopathy,age,systolic and diastolic blood pressure (BP),fetal birth weight,and various biochemical parameters.Spearman Rank Correlation and Ordinal Regression were used for statistical analysis.P<0.05was considered significant.Results The severity of retinopathy was found to be inversely related to fetal birth weight (β=□0.001,P=0.000) and positively related to serum uric acid level(β=0.14,P=0.000)in the patients with preeclampsia.Conclusions The severity of retinopathy in preeclampsia is directly related to the level of placental insufficiency and intrauterine growth retardation.