中华结核和呼吸杂志
中華結覈和呼吸雜誌
중화결핵화호흡잡지
Chinese Journal of Tuberculosis and Respiratory Diseases
2010年
6期
419-421
,共3页
王萍%朱敏立%宋海晶%肖庆%孔新春%彭文鸿%邢士玲%郭爱敏
王萍%硃敏立%宋海晶%肖慶%孔新春%彭文鴻%邢士玲%郭愛敏
왕평%주민립%송해정%초경%공신춘%팽문홍%형사령%곽애민
流感病毒A型,H1N1亚型%聚集
流感病毒A型,H1N1亞型%聚集
류감병독A형,H1N1아형%취집
Influenza A,H1N1 subtype%Agglomeration
目的 观察群体发病的新型甲型H1N1流感(简称甲型流感)患者的临床特点,探讨奥司他韦和中药治疗与预后的相关性. 方法 分析2009年6月份、8月份和10月份发生的3起聚集性发病的234例患者的临床资料,比较单纯中药治疗和中药+奥司他韦治疗患者的发热持续时间、临床症状消失时间和住院时间. 结果 年龄、体温、血常规及肝肾功能等基线资料两组分布均衡.发热持续时间中药组与中药+奥司他韦组[(28.9±24.3)和(29.6±13.2)h]比较差异无统计学意义(t=-0.03,P>0.05),临床症状消失时间[(5±2.5)和(5±2.6)d]和住院时间[(7.5 ±2.5)和(7.3±3.2)d],两组比较差异均无统计学意义(t值为0.097和-1.16,P>0.05).将高热患者(体温≥39℃)和中低热患者(体温<39℃)进行分层分析,结果显示在中低热患者中,中药组与中药+奥司他韦组的发热持续时间[(17.3 ±12.9)和(22.0±13.0)h]和症状消失时间[(3.4±1.5)和(3.1±1.8)d]比较,差异无统计学意义(t值为1.03和0.43,P>0.05);在高热患者中,虽然两组的症状消失时间差异无统计学意义(中位数为3.5 d和4 d,Z=0.47,P>0.05),但两组的发热持续时间差异有统计学意义(Z=3.354,P<0.01),中药组发热持续时间(中位数为40.5 h)明显长于中药+奥司他韦组(中位数为22 h). 结论 清热祛瘟中药治疗甲型流感有效,轻症患者可以不用奥司他韦治疗.奥司他韦能缩短高热患者的发热时间,提倡早期应用.
目的 觀察群體髮病的新型甲型H1N1流感(簡稱甲型流感)患者的臨床特點,探討奧司他韋和中藥治療與預後的相關性. 方法 分析2009年6月份、8月份和10月份髮生的3起聚集性髮病的234例患者的臨床資料,比較單純中藥治療和中藥+奧司他韋治療患者的髮熱持續時間、臨床癥狀消失時間和住院時間. 結果 年齡、體溫、血常規及肝腎功能等基線資料兩組分佈均衡.髮熱持續時間中藥組與中藥+奧司他韋組[(28.9±24.3)和(29.6±13.2)h]比較差異無統計學意義(t=-0.03,P>0.05),臨床癥狀消失時間[(5±2.5)和(5±2.6)d]和住院時間[(7.5 ±2.5)和(7.3±3.2)d],兩組比較差異均無統計學意義(t值為0.097和-1.16,P>0.05).將高熱患者(體溫≥39℃)和中低熱患者(體溫<39℃)進行分層分析,結果顯示在中低熱患者中,中藥組與中藥+奧司他韋組的髮熱持續時間[(17.3 ±12.9)和(22.0±13.0)h]和癥狀消失時間[(3.4±1.5)和(3.1±1.8)d]比較,差異無統計學意義(t值為1.03和0.43,P>0.05);在高熱患者中,雖然兩組的癥狀消失時間差異無統計學意義(中位數為3.5 d和4 d,Z=0.47,P>0.05),但兩組的髮熱持續時間差異有統計學意義(Z=3.354,P<0.01),中藥組髮熱持續時間(中位數為40.5 h)明顯長于中藥+奧司他韋組(中位數為22 h). 結論 清熱祛瘟中藥治療甲型流感有效,輕癥患者可以不用奧司他韋治療.奧司他韋能縮短高熱患者的髮熱時間,提倡早期應用.
목적 관찰군체발병적신형갑형H1N1류감(간칭갑형류감)환자적림상특점,탐토오사타위화중약치료여예후적상관성. 방법 분석2009년6월빈、8월빈화10월빈발생적3기취집성발병적234례환자적림상자료,비교단순중약치료화중약+오사타위치료환자적발열지속시간、림상증상소실시간화주원시간. 결과 년령、체온、혈상규급간신공능등기선자료량조분포균형.발열지속시간중약조여중약+오사타위조[(28.9±24.3)화(29.6±13.2)h]비교차이무통계학의의(t=-0.03,P>0.05),림상증상소실시간[(5±2.5)화(5±2.6)d]화주원시간[(7.5 ±2.5)화(7.3±3.2)d],량조비교차이균무통계학의의(t치위0.097화-1.16,P>0.05).장고열환자(체온≥39℃)화중저열환자(체온<39℃)진행분층분석,결과현시재중저열환자중,중약조여중약+오사타위조적발열지속시간[(17.3 ±12.9)화(22.0±13.0)h]화증상소실시간[(3.4±1.5)화(3.1±1.8)d]비교,차이무통계학의의(t치위1.03화0.43,P>0.05);재고열환자중,수연량조적증상소실시간차이무통계학의의(중위수위3.5 d화4 d,Z=0.47,P>0.05),단량조적발열지속시간차이유통계학의의(Z=3.354,P<0.01),중약조발열지속시간(중위수위40.5 h)명현장우중약+오사타위조(중위수위22 h). 결론 청열거온중약치료갑형류감유효,경증환자가이불용오사타위치료.오사타위능축단고열환자적발열시간,제창조기응용.
Objective To describe the clinical characteristics of 3 community outbreaks of the novel influenza A (H1N1),and to compare the treatment effects of the traditional Chinese medicine with or without Oseltamivir. Method The clinical records of 234 patients in 3 community outbreaks of the novel influenga A(H1N1)infection in June (n=56),August (n=96)and October (n=82) of 2009 were analyzed,and the treatment effects of the traditional Chinese medicine with or without Oseltamivir were evaluated. Results The baseline characteristics,including age,temperature,indices of blood tests,hepatic and renal functions were distributed evenly between the 2 treatment groups.The overall analysis suggested that there was no significant difference between the 2 treatment groups in the duration of clinical symptoms(P>0.05),the duration of fever(P>0.05),and the hospitalization days(P>0.05).However,an analysis stratified by the temperature (≥39℃ or <39℃)suggested that patients treated by the traditional Chinese medicine with Oseltamivir tended to suffer a shorter duration of fever [40.5(37.3.42.0) vs 22.0(10.5,30.8)hr,P<0.01]]in the higher temperature group. Conclusions The traditional Chinese medicine was equivalent to oseltamivir in treating patients with the novel influenza A (H1N1) infection with lower temperature (<39℃).Oseltamivir was effective in shortening the duration of fever in patients with temperature higher than 39℃.
