CAJ | 학술논문

目的探讨转化生长因子β(TGF-β)和转化生长影响因子(TGIF)在子宫内膜异位症的发生发展中的作用.方法采用免疫组织化学法检测子宫内膜异位症在位内膜(30例),异位内膜(30例)及正常子宫内膜(40例)中TGF-β和TGIF的表达.结果异位内膜组TGF-β的表达高于对照组和在位内膜组(P<0.05);在位内膜组与对照组TGF-β的表达差异无统计学意义(P>0.05).异位内膜组TGIF的表达低于在位内膜组和对照组(P<0.05).在位内膜组TGIF的表达与时照组差异无统计学意义(P>0.05).异位内膜组及在位内膜组的TGF-β蛋白与TGIF蛋白表达均呈负相关(rs=-0.769,-0.549,P<0.05).结论子宫内膜异位症的异位内膜组织中TGF-β与TGIF的异常表达可能参与了子宫内膜异位症的发生、发展.
목적 탐토전화생장인자β(TGF-β)화전화생장영향인자(TGIF)재자궁내막이위증적발생발전중적작용.방법 채용면역조직화학법검측자궁내막이위증재위내막(30례),이위내막(30례)급정상자궁내막(40례)중TGF-β화TGIF적표체.결과 이위내막조TGF-β적표체고우대조조화재위내막조(P<0.05);재위내막조여대조조TGF-β적표체차이무통계학의의(P>0.05).이위내막조TGIF적표체저우재위내막조화대조조(P<0.05).재위내막조TGIF적표체여시조조차이무통계학의의(P>0.05).이위내막조급재위내막조적TGF-β단백여TGIF단백표체균정부상관(rs=-0.769,-0.549,P<0.05).결론 자궁내막이위증적이위내막조직중TGF-β여TGIF적이상표체가능삼여료자궁내막이위증적발생、발전.
Objective To explore the role of TGF-βand TGIF in the pathogenesis of endometriosis. Methods The expression of TGF-β and TGIF was detected by immunohistochemistry method in the ectopic and eutopic endometrium of 30 cases with endometriosis (ec-topic endometrium group and eutopic endometrium group) and in the normal endometrium of 40 cases without endometriosis (control group). Result The expression of TGF -β in ectopic endometrium group was significantly higher than that in eutopic endometrium group and control group (P < 0.05). There was no significant difference in the expression of TGF- βbetween eutopic endometrium group and control group(P > 0.05). The expression of TGIF in ectopic endometrium group was significantly lower than that in eutopic endometrium group and control group( P <0.05). There was no significant difference in the expression of TGIF between eutopic endometrium group and control group(P > 0.05). There were negative correlation between the expressions of TGF - β and TGIF in ectopic endometrium group and eutopic endome-trium group(rs= - 0.769, - 0.549, P < 0.05). Conclusion The abnormal expression of TGF-β and TGIF in ectopic endometrium of pa-tients with endometriosis may be associated with the genesis and progression of endometriosis.