中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2010年
12期
844-848
,共5页
米姣平%樊韵平%王静清%夏文彤
米姣平%樊韻平%王靜清%夏文彤
미교평%번운평%왕정청%하문동
倍氯米松%气雾喷射剂%计算机系统%随机对照试验%腺样体肥大
倍氯米鬆%氣霧噴射劑%計算機繫統%隨機對照試驗%腺樣體肥大
배록미송%기무분사제%계산궤계통%수궤대조시험%선양체비대
Beclomethasone%Aerosol propellants%Computer systems%Randomized controlled trials%Adenoid hypertrophy
目的 系统评价局部使用倍氯米松气雾剂对儿童腺样体肥大的有效性、安全性.方法 计算机检索临床随机对照试验资料库Cochrane图书馆、MEDLINE、EMbase、维普中文期刊数据库(VIP)、万方学位论文数据库、中国期刊全文数据库(CNKI)、中国医疗健康年库等,并辅以手工检索相关会议论文集、药厂资料及所有检索到的文献的参考文献.检索截至2009年1月.收集倍氯米松鼻喷雾剂对腺样体肥大治疗作用的随机对照试验(RCT)及半随机对照试验(qRCT).由两名研究者按Cochrane系统评价方法,独立选择试验,提取资料、评价纳入研究的方法学质量,并提取有效的数据进行分析.结果 共有3篇随机对照试验符合纳入标准,但由于3项研究存在异质性,无法进行Meta分析,故仅进行描述性分析.3篇随机对照试验表明应用336、400 μg/d的倍氯米松鼻喷雾剂能够改善患者鼻塞症状,缩小腺样体的体积.结论 在初期使用较高剂量(336、400 μg/d)加随后长期半量的倍氯米松鼻喷雾剂能够改善腺样体肥大所致的儿童鼻塞症状.其改善原因在于能够减小腺样体的体积.但迄今随机对照试验较少,尚需大样本、高质量的随机对照实验进一步证实.
目的 繫統評價跼部使用倍氯米鬆氣霧劑對兒童腺樣體肥大的有效性、安全性.方法 計算機檢索臨床隨機對照試驗資料庫Cochrane圖書館、MEDLINE、EMbase、維普中文期刊數據庫(VIP)、萬方學位論文數據庫、中國期刊全文數據庫(CNKI)、中國醫療健康年庫等,併輔以手工檢索相關會議論文集、藥廠資料及所有檢索到的文獻的參攷文獻.檢索截至2009年1月.收集倍氯米鬆鼻噴霧劑對腺樣體肥大治療作用的隨機對照試驗(RCT)及半隨機對照試驗(qRCT).由兩名研究者按Cochrane繫統評價方法,獨立選擇試驗,提取資料、評價納入研究的方法學質量,併提取有效的數據進行分析.結果 共有3篇隨機對照試驗符閤納入標準,但由于3項研究存在異質性,無法進行Meta分析,故僅進行描述性分析.3篇隨機對照試驗錶明應用336、400 μg/d的倍氯米鬆鼻噴霧劑能夠改善患者鼻塞癥狀,縮小腺樣體的體積.結論 在初期使用較高劑量(336、400 μg/d)加隨後長期半量的倍氯米鬆鼻噴霧劑能夠改善腺樣體肥大所緻的兒童鼻塞癥狀.其改善原因在于能夠減小腺樣體的體積.但迄今隨機對照試驗較少,尚需大樣本、高質量的隨機對照實驗進一步證實.
목적 계통평개국부사용배록미송기무제대인동선양체비대적유효성、안전성.방법 계산궤검색림상수궤대조시험자료고Cochrane도서관、MEDLINE、EMbase、유보중문기간수거고(VIP)、만방학위논문수거고、중국기간전문수거고(CNKI)、중국의료건강년고등,병보이수공검색상관회의논문집、약엄자료급소유검색도적문헌적삼고문헌.검색절지2009년1월.수집배록미송비분무제대선양체비대치료작용적수궤대조시험(RCT)급반수궤대조시험(qRCT).유량명연구자안Cochrane계통평개방법,독립선택시험,제취자료、평개납입연구적방법학질량,병제취유효적수거진행분석.결과 공유3편수궤대조시험부합납입표준,단유우3항연구존재이질성,무법진행Meta분석,고부진행묘술성분석.3편수궤대조시험표명응용336、400 μg/d적배록미송비분무제능구개선환자비새증상,축소선양체적체적.결론 재초기사용교고제량(336、400 μg/d)가수후장기반량적배록미송비분무제능구개선선양체비대소치적인동비새증상.기개선원인재우능구감소선양체적체적.단흘금수궤대조시험교소,상수대양본、고질량적수궤대조실험진일보증실.
Objective To systematically review the efficacy and safety of beclomethosone nasal spray in the treatment of chronic adenoid hypertrophy in children. Methods We computerized searches of the Cochrane Central Register of ControUed Trials (CENTRAL) (issue1,009), MEDLINE (1950 to August 2008) ,EMbase (1984 to August 2008), CNKI (1994 to September 2008), and VIP (1989 to August 2008), WANFANG DATA, Annual Review-s and Elsevier Science. Also the reference lists of all papers were identified for further trials. All searches were initially performed in May 2007 and updated in April 2009. Randomized controlled trials (RCT) and quasi-RCTs were identified and analyzed according to the Cochrane Handbook for Systematic Reviews of Interventions. Results Three RCT were included. Meta-analysis was not performed due to heterogeneity and the data were summarized in a narrative formal The trials showed that higher doses of beclomethasone (336 μg/d, 400 μg/d) might improve the nasal obstruction symptoms and reduce adenoid size in children with adenoid hypertrophy. Conclusions Higher and subsequently half doses of beclomethasone (336 g/d, 400 g/d) can improve the nasal obstruction symptoms in children with adenoid hypertrophy. The improvement appears to be associated with a reduction of adenoid size. Beacuse of a lack of the RCT, further studies are required to support the use of beclomethasone as a first-line approach for these children.
