CAJ | 학술논문

为探讨预防型抗氟剂(Ⅰ型-1)［PAA(Ⅰ-1)］的慢性毒性，选用64只健康Wistar大鼠，随机分成4组，即A组(400 mg/kg.d)，B组(80 mg/kg.d)，C组(16 mg/kg.d)和D组(对照组)。灌胃给药，进行了为期6个月的实验研究。结果表明，除高剂量组动物体重增长缓慢，尿常规、白细胞和血小板计数较低(但与对照组比较差异无显著性)，血清总蛋白、白蛋白、总胆固醇、甘油三酯，血清丙氨酸转氨酶、碱性磷酸酶、淀粉酶、尿素氮无显著变化，血清超氧化物歧化酶活性和微量元素高于对照组，但差异也无显著性。提示，［PAA(Ⅰ-1)］无明显的慢性毒作用。
위탐토예방형항불제(Ⅰ형-1)［PAA(Ⅰ-1)］적 만성독성，선용64지건강Wistar대서，수궤분성4조，즉A조(400 mg/kg.d)，B조(80 mg/kg.d)，C조(16 mg/kg.d)화D조(대조조)。관위급약，진행료위기6개월적실험연구。결과표명，제고제량조동물체중증장완만，뇨상규、백세포화혈소판계수교저(단여대조조비교차이무현저성)，혈청총단백、백단백、총담고순、감유삼지，혈청병안산전안매、감 성린산매、정분매、뇨소담무현저변화，혈청초양화물기화매활성화미량원소고우대조조， 단차이야무현저성。제시，［PAA(Ⅰ-1)］무명현적만성독작용。
In order to study the chronic toxicity of preventive anti-fluo rine agent(Ⅰ-1),64 healthy Wistar rats were randomly divided into 4 groups.Group A(400 mg/kg.d)，B(80 mg/kg.d)，and C(16 mg/kg.d)were treated with preventive anti-fluorine agent(Ⅰ-1)，and group D served as negative control.The body weight,organ index,urine and blood analysis and biochemistry target were examined in all rats.The results showed that only in group A,the increase of the body weight slackened,and there were some decrease in routine urine test,leucocyte and platelet count,however,with no significant difference.No apparent difference was found in the total protein and albumin contents of blood serum,CT,TG,ALT,AKP,and BUN.The activity of SOD and trace elements increased without significant difference.All these showed that the preventive anti-fluorine agent(I\|1)exerts no significant chronic toxicity.