CAJ | 학술논문

目的　探讨煤尘职业接触者和早期煤工尘肺患者BAL液中表面活性物质含量改变特点及其意义。方法　采煤工人23人，按X线诊断煤工尘肺期别分为0期(煤尘接触者)组7人、0＋组8人和Ⅰ期组8人，并取健康农民7人为对照组。经纤支镜支气管肺泡灌洗(BAL)收集BAL液，测定表面活性蛋白A(SP-A)和磷脂(PL)及其组分含量。结果　0期组BAL液中SP-A含量、SP-A/PL和PG/PI明显高于对照组(P＜0.01)，且随煤工尘肺期别的增加而有降低趋势。结论　BAL液中SP-A含量、SP-A/PL和PG/PI升高可能是煤尘接触的早期效应指标。
목적　탐토매진직업접촉자화조기매공진폐환자BAL액중표면활성물질함량개변특점급기의의。방법　채매공인23인，안X선진단매공진폐기별분위0기(매진접촉자)조7인、0＋조8인화Ⅰ기조8인，병취건강농민7인위대조조。경섬지경지기관폐포관세(BAL)수집BAL액，측정표면활성단백A(SP-A)화린지(PL)급기조분함량。결과　0기조BAL액중SP-A함량、SP-A/PL화PG/PI명현고우대조조(P＜0.01)，차수매공진폐기별적증가이유강저추세。결론　BAL액중SP-A함량、SP-A/PL화PG/PI승고가능시매진접촉적조기효응지표。
Objective　To study the change of surfactant levels and its significance in BAL fluids after coal mine dust exposure and of early coal workers' pneumoconiosis(CWP).Methods　7 coal mine dust exposurers(stage 0 group) and 8 coal miners with stage Ⅰ　CWP and 8 coal miners with stage 0+ CWP according to X-ray diagnosis and 7 healthy smoking peasants as a control group were selected. The BAL fluid was collected by fibroendoscopy and the levels of surfactant protein A(SP-A) and phospholipid (PL) levels in the BAL fluids were measured with ELISA and HPLC respectively.Results　The SP-A level, SP-A/PL and PG/PI value in BAL fluids in stage 0 group is higher than that in the control group (P＜0.01), and have decrease trend with increasing degree of CWP. Conclusion　The increase of SP-A level, SP-A/PL and PG/PI value in BAL fluids might be served as effective biomarkers for coal mine dust exposure.