CAJ | 학술논문

目的通过动物实验观察参苓白术散对正常动物、胃轻瘫模型动物和腹泻模型动物胃肠动力的影响,以探讨该方对胃肠动力影响的作用机制.方法采用正常动物、胃轻瘫动物和腹泻动物,研究参苓白术散对其胃肠动力的影响.结果参苓白术散能明显加快正常小鼠胃排空液体和固体的速度,降低胃内残留量,与空白组比较有显著性差异(P<0.05);能显著提高阿托品和多巴胺所致胃轻瘫小鼠的胃排空能力,并降低胃内固体残留率,能明显减少脾虚大鼠和番泻叶所致腹泻小鼠腹泻次数及腹泻量,与模型组比较有显著性差异(P<0.01或P<0.05).结论参苓白术散能明显改善胃肠动力,具有双向调节作用.
목적 통과동물실험관찰삼령백술산대정상동물、위경탄모형동물화복사모형동물위장동력적영향,이탐토해방대위장동력영향적작용궤제.방법 채용정상동물、위경탄동물화복사동물,연구삼령백술산대기위장동력적영향.결과 삼령백술산능명현가쾌정상소서위배공액체화고체적속도,강저위내잔류량,여공백조비교유현저성차이(P<0.05);능현저제고아탁품화다파알소치위경탄소서적위배공능력,병강저위내고체잔류솔,능명현감소비허대서화번사협소치복사소서복사차수급복사량,여모형조비교유현저성차이(P<0.01혹P<0.05).결론 삼령백술산능명현개선위장동력,구유쌍향조절작용.
Objective To study the effect of Shenlingbaizhu Powder on gastrointestinal motility and its mechanisms.Methods Use normal animals, model animals with diabetic gastroparesis and model animals with diarrhea to study the influence of Shenlingbaizhu Powder on gastrointestinal motility. Results Shenlingbaizhu Powder could significantly increase the gastric emptying and decrease the residual volume of stomach in normal animals (P<0.01 or P<0.05);Shenlingbaizhu Powder could significantly increase the ability for gastric emptying and decrease the rate of solid residual amount of stomach in the model mice with diabetic gastroparesis induced by atropine and Dopamine (P<0.01 or P<0.05). Compared with atropine groups and Dopamine groups, Shenlingbaizhu Powder could significantly decrease the frequency and amount of diarrhea in the rats with splenic asthenia and the mice with diarrhea induced by folium sennae (P<0.01 or P<0.05).Conclusion Shenlingbaizhu Powder can improve gastrointestinal motility, and this effect is of two-ways regulation.