CAJ | 학술논문

相对性肾上腺皮质功能不全是脓毒症患儿病情恶化因素之一,目前临床诊断尚存在争议.巨噬细胞移动抑制因子能抵抗糖皮质激素的抗炎活性,在机体炎症反应中起重要作用.巨噬细胞移动抑制因子与糖皮质激素之间相互作用可能引起相对性肾上腺皮质功能不全.因此,巨噬细胞移动抑制因子可能是临床上诊断相对性肾皮质功能不全的一个重要指标.
상대성신상선피질공능불전시농독증환인병정악화인소지일,목전림상진단상존재쟁의.거서세포이동억제인자능저항당피질격소적항염활성,재궤체염증반응중기중요작용.거서세포이동억제인자여당피질격소지간상호작용가능인기상대성신상선피질공능불전.인차,거서세포이동억제인자가능시림상상진단상대성신피질공능불전적일개중요지표.
The hypothalamo-pituitary-adrenal (HPA) axis modulates the inflammatory response during sepsis.Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses in sepsis and septic shock.MIF counteracts the anti-inflammatory activity of glucocorticoid (GC).The interaction of GC and MIF might cause adrenal insufficiency.MIF could be a valuable clinical marker of adrenal insufficiency in sepsis.