中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2011年
12期
1131-1134
,共4页
王洪格%田景毅%张静静%张津
王洪格%田景毅%張靜靜%張津
왕홍격%전경의%장정정%장진
早产儿视网膜病变%筛查%相关因素
早產兒視網膜病變%篩查%相關因素
조산인시망막병변%사사%상관인소
Retinopathy of prematurity%Screening%Risk factor
背景 早产儿视网膜病变(ROP)威胁早产儿的视功能,在早产儿中进行ROP筛查并早期进行干预对保存患儿的视力有着极其重要的意义.目前相关的筛查工作已相继在中国多个地区开展或完成,但山东省济南地区尚缺乏相关的筛查研究.目的 分析山东省济南地区ROP的筛查结果以及相关影响因素.方法 采用横断面调查研究设计.对2008年6月至2010年6月在山东省眼科医院眼底病科就诊且来自山东省济南地区的早产儿和低体重儿144例288眼进行筛查.筛查标准参照2004年中国卫生部颁发的ROP筛查标准和国内多中心的筛查结果,纳入对象为出生体重≤2500 g或矫正胎龄≤34周的早产儿和低体重儿,ROP分类标准采用ROP国际分类标准.检查前询问、记录受检儿的病史并对全身情况进行评估.对ROP患儿组与眼底正常儿组的平均出生孕周和出生体重、患儿有持续吸氧史者所占比例进行统计学分析.结果 本次调查发现,济南地区符合早产儿和低体重儿标准者144例288眼,共筛查出不同程度的ROP患儿15例30眼,其中男8例,女7例；均为双眼患病；ROP检出率为10.42％.ROP患儿出生孕周平均为(30.85±1.79)周;出生体重平均为(1408.89±259.93)g.其中ROP 1期者有6例12眼,2期者4例8眼,3期伴附加病变者4例8眼,5期者1例2眼.受检者中129例眼底正常,出生孕周平均为(32.38±1.48)周,出生体重平均为(1763.19±338.62)g.ROP组患儿的出生孕周明显短于眼底正常组,差异有统计学意义(t=3.71,P＜0.01),ROP组患儿的出生体重明显低于眼底正常组,差异有统计学意义(t=2.88,P＜0.01).眼底正常组与ROP组有持续吸氧史者所占的比例分别为58.91％和60.00％,差异无统计学意义(P=1.000).依据中国卫生部的筛查标准所得的ROP检出率为12.93％(15/116),按山东省的标准检出率为10.42％(15/144),差异无统计学意义(x2=0.398,P=0.528).结论 济南地区ROP检出率与国内其他地区报道的数据较接近.中国卫生部制定的ROP筛查标准适合济南地区的ROP筛查工作.孕周短和出生体重低是导致ROP发生的危险因素.
揹景 早產兒視網膜病變(ROP)威脅早產兒的視功能,在早產兒中進行ROP篩查併早期進行榦預對保存患兒的視力有著極其重要的意義.目前相關的篩查工作已相繼在中國多箇地區開展或完成,但山東省濟南地區尚缺乏相關的篩查研究.目的 分析山東省濟南地區ROP的篩查結果以及相關影響因素.方法 採用橫斷麵調查研究設計.對2008年6月至2010年6月在山東省眼科醫院眼底病科就診且來自山東省濟南地區的早產兒和低體重兒144例288眼進行篩查.篩查標準參照2004年中國衛生部頒髮的ROP篩查標準和國內多中心的篩查結果,納入對象為齣生體重≤2500 g或矯正胎齡≤34週的早產兒和低體重兒,ROP分類標準採用ROP國際分類標準.檢查前詢問、記錄受檢兒的病史併對全身情況進行評估.對ROP患兒組與眼底正常兒組的平均齣生孕週和齣生體重、患兒有持續吸氧史者所佔比例進行統計學分析.結果 本次調查髮現,濟南地區符閤早產兒和低體重兒標準者144例288眼,共篩查齣不同程度的ROP患兒15例30眼,其中男8例,女7例；均為雙眼患病；ROP檢齣率為10.42％.ROP患兒齣生孕週平均為(30.85±1.79)週;齣生體重平均為(1408.89±259.93)g.其中ROP 1期者有6例12眼,2期者4例8眼,3期伴附加病變者4例8眼,5期者1例2眼.受檢者中129例眼底正常,齣生孕週平均為(32.38±1.48)週,齣生體重平均為(1763.19±338.62)g.ROP組患兒的齣生孕週明顯短于眼底正常組,差異有統計學意義(t=3.71,P＜0.01),ROP組患兒的齣生體重明顯低于眼底正常組,差異有統計學意義(t=2.88,P＜0.01).眼底正常組與ROP組有持續吸氧史者所佔的比例分彆為58.91％和60.00％,差異無統計學意義(P=1.000).依據中國衛生部的篩查標準所得的ROP檢齣率為12.93％(15/116),按山東省的標準檢齣率為10.42％(15/144),差異無統計學意義(x2=0.398,P=0.528).結論 濟南地區ROP檢齣率與國內其他地區報道的數據較接近.中國衛生部製定的ROP篩查標準適閤濟南地區的ROP篩查工作.孕週短和齣生體重低是導緻ROP髮生的危險因素.
배경 조산인시망막병변(ROP)위협조산인적시공능,재조산인중진행ROP사사병조기진행간예대보존환인적시력유착겁기중요적의의.목전상관적사사공작이상계재중국다개지구개전혹완성,단산동성제남지구상결핍상관적사사연구.목적 분석산동성제남지구ROP적사사결과이급상관영향인소.방법 채용횡단면조사연구설계.대2008년6월지2010년6월재산동성안과의원안저병과취진차래자산동성제남지구적조산인화저체중인144례288안진행사사.사사표준삼조2004년중국위생부반발적ROP사사표준화국내다중심적사사결과,납입대상위출생체중≤2500 g혹교정태령≤34주적조산인화저체중인,ROP분류표준채용ROP국제분류표준.검사전순문、기록수검인적병사병대전신정황진행평고.대ROP환인조여안저정상인조적평균출생잉주화출생체중、환인유지속흡양사자소점비례진행통계학분석.결과 본차조사발현,제남지구부합조산인화저체중인표준자144례288안,공사사출불동정도적ROP환인15례30안,기중남8례,녀7례；균위쌍안환병；ROP검출솔위10.42％.ROP환인출생잉주평균위(30.85±1.79)주;출생체중평균위(1408.89±259.93)g.기중ROP 1기자유6례12안,2기자4례8안,3기반부가병변자4례8안,5기자1례2안.수검자중129례안저정상,출생잉주평균위(32.38±1.48)주,출생체중평균위(1763.19±338.62)g.ROP조환인적출생잉주명현단우안저정상조,차이유통계학의의(t=3.71,P＜0.01),ROP조환인적출생체중명현저우안저정상조,차이유통계학의의(t=2.88,P＜0.01).안저정상조여ROP조유지속흡양사자소점적비례분별위58.91％화60.00％,차이무통계학의의(P=1.000).의거중국위생부적사사표준소득적ROP검출솔위12.93％(15/116),안산동성적표준검출솔위10.42％(15/144),차이무통계학의의(x2=0.398,P=0.528).결론 제남지구ROP검출솔여국내기타지구보도적수거교접근.중국위생부제정적ROP사사표준괄합제남지구적ROP사사공작.잉주단화출생체중저시도치ROP발생적위험인소.
Background Retinopathy of prematurity (ROP) threats the visual function of prematurity patients.The screen of ROP is very important for the early prevention and treatment.Some relevant works have performed in several region and cities in China.But the survey data is still lack in Shandong province.Objective This work was to survey and analyze the screening result of ROP in Jinan city and assess the risk factors for ROP.Methods A cross-sectional study was designed.Two hundreds and eighty-eight eyes of 144 cases with low birth weight or prematurity were clinically examined in Shandong Eye Hospital from June,2008 to June,2010.The screening criteria was established based on the ROP screening guidelines and the outcome implemented by Ministry of Public Health with minor modification,including newborn infants with birth weight of 2500 grams or less and gestational age of 34 weeks or less.The history and systemic status were recorded,and the screening results were compared with those obtained from the national screening criteria.Gestation age and birth weight between the infants with and without ROP were compared using student t-test.The ratios of persistent oxygen inhalation were tested by Fisher' s exact test.Results In all examined infants,30 eyes of 15 cases (10.42％) developed ROP,including 12 eyes of 6 cases suffering from stage Ⅰ,8 eyes of 4 cases from stage Ⅱ,8 eyes of 4 cases from stage Ⅲ with plus disease and 2 eyes of 1 case from stage V.In ROP patients,gestation age ranged from 27 weeks to 33 weeks with the average weeks of 30.85±1.79,and the birth weight ranged from 910 grams to 1980 grams with the average weight (1408.89±259.93)grams.Statistical analysis showed that the gestation age and birth weight in prematurity infants with normal fundus group were (32.38±1.48) weeks ranged from 28 weeks to 35 weeks and (1763.19±338.62) grams ranged from 1310 grams to 2450 grams respectively,showing a shorter gestation age (t=3.71,P＜0.01 ) and a lower birth weight ( t =2.88,P＜0.01 ) in ROP infants.The ratios of persistent oxygen inhalation in normal fundus group and ROP group were 58.91％ and 60.00％,respectively with the insignificant difference between them (P =1.000).Conclusions The incidence of ROP is 10.42％ in the present study,which is consistent with the result from other region in China,suggesting that the national criteria is practical for the ROP screening in Jinan region.Prematurity and low birth weight are identified as the high risk factors of ROP.
