中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
13期
35-37
,共3页
结肠肿瘤%Survivin蛋白%血管内皮生长因子
結腸腫瘤%Survivin蛋白%血管內皮生長因子
결장종류%Survivin단백%혈관내피생장인자
Colonic carcinoma%Survivin%Vascular endothelial growth factor
目的 探讨Survivin蛋白和血管内皮生长因子(VEGF)在结肠癌组织中的表达及其与肿瘤进展的关系.方法 采用免疫组化SP法检测80例结肠癌组织中Survivin蛋白和VEGF表达情况,并以20例正常结肠组织作为对照.结果 结肠癌组织中Survivin蛋白和VEGF表达显著高于正常结肠组织(P＜0.05).结肠癌患者中Ⅲ-Ⅳ期、淋巴结转移患者的Survivin蛋白和VEGF阳性表达率分别高于Ⅰ-Ⅱ期和无淋巴结转移患者(P＜0.05).Survivin蛋白和VEGF表达呈正相关(r=0.563,P＜0.05).结论 结肠癌组织中Survivin蛋白和VEGF 的表达水平明显升高,它们在结肠癌的浸润转移中起到了重要的作用,可作为反映结肠癌进展的生物学指标.
目的 探討Survivin蛋白和血管內皮生長因子(VEGF)在結腸癌組織中的錶達及其與腫瘤進展的關繫.方法 採用免疫組化SP法檢測80例結腸癌組織中Survivin蛋白和VEGF錶達情況,併以20例正常結腸組織作為對照.結果 結腸癌組織中Survivin蛋白和VEGF錶達顯著高于正常結腸組織(P＜0.05).結腸癌患者中Ⅲ-Ⅳ期、淋巴結轉移患者的Survivin蛋白和VEGF暘性錶達率分彆高于Ⅰ-Ⅱ期和無淋巴結轉移患者(P＜0.05).Survivin蛋白和VEGF錶達呈正相關(r=0.563,P＜0.05).結論 結腸癌組織中Survivin蛋白和VEGF 的錶達水平明顯升高,它們在結腸癌的浸潤轉移中起到瞭重要的作用,可作為反映結腸癌進展的生物學指標.
목적 탐토Survivin단백화혈관내피생장인자(VEGF)재결장암조직중적표체급기여종류진전적관계.방법 채용면역조화SP법검측80례결장암조직중Survivin단백화VEGF표체정황,병이20례정상결장조직작위대조.결과 결장암조직중Survivin단백화VEGF표체현저고우정상결장조직(P＜0.05).결장암환자중Ⅲ-Ⅳ기、림파결전이환자적Survivin단백화VEGF양성표체솔분별고우Ⅰ-Ⅱ기화무림파결전이환자(P＜0.05).Survivin단백화VEGF표체정정상관(r=0.563,P＜0.05).결론 결장암조직중Survivin단백화VEGF 적표체수평명현승고,타문재결장암적침윤전이중기도료중요적작용,가작위반영결장암진전적생물학지표.
[Objective] To investigate the expression and clinical significance of Survivin and vascular endothelial growth factor(VEGF)in colonic carcinoma tissue.[Methods] The expression levels of Survivin and VEGF were measured by immunohistochemistry in the resected specimens from 80 patients with colonic carcinoma and 20 controls.[Results] The positive rates of Survivin and VEGF were significantly higher in the colonic carcinoma tissues than those in the controls(P ＜ 0.05).The positive rates of Survivin and VEGF in Ⅲ-Ⅳ stage were significantly higher than those of patients in Ⅰ-Ⅱ stage tumor (P ＜ 0.05).The positive rates of Survivin and VEGF in lymph node metastasis tumor were significantly higher than those of patients in non metastasis tumor(P＜ 0.05).There was positive correlation between the expression of Survivin and VEGF(r=0.563,P ＜ 0.05).[Conclusions] Survivin and VEGF expression levels in colonic carcinoma increases markedly,which plays an important role in the progression of colonic carcinoma.
