CAJ | 학술논문

目的探讨梅尼埃病(Meniere′s disease)患者与组织相容性白细胞抗原（histocompatibility leukocyte antigen，HLA）-II类基因DRB1等位基因的关联。方法采用聚合酶链反应-序列特异性引物（polymerase chain reaction-sequence specific primers，PCR-SSP）技术。测试60例梅尼埃病患者和85名健康人对照。结果患者组HLA-DRB1*3+5+6+8基因组集团总数高于健康对照组，相对危险性为1.99，P<0.05，患者组HLA-DRB1*09明显低于健康对照组，相对危险性为0.17，P<0.01。结论梅尼埃病患者HLA-DRB1*09显著下降，提示HLA-DRB1*09可能是梅尼埃病的保护性基因。
목적탐토매니애병(Meniere′s disease)환자여조직상용성백세포항원（histocompatibility leukocyte antigen，HLA）-II류기인DRB1등위기인적관련。방법채용취합매련반응-서렬특이성인물（polymerase chain reaction-sequence specific primers，PCR-SSP）기술。측시60례매니애병환자화85명건강인대조。결과환자조HLA-DRB1*3+5+6+8기인조집단총수고우건강대조조，상대위험성위1.99，P<0.05，환자조HLA-DRB1*09명현저우건강대조조，상대위험성위0.17，P<0.01。결론매니애병환자HLA-DRB1*09현저하강，제시HLA-DRB1*09가능시매니애병적보호성기인。
Objective　To investigate the relation between histocompatibility leukocyte antigen （HLA）-class II DRB1 and Meniere′s disease in Chinese. Methods　Polymerase chain reaction-sequence specific primers(PCR-SSP)technique was used. HLA-class II allele distribution were measured in 60 patients with Meniere′s disease, in comparison with those in 85 normal population. Result　The results showed that the frequency of DRB1*09 allele was significantly lower in Meniere′s disease patients than in those of controls(relative risk=0.17,P<0.01). Conclusion　HLA-DRB1*09 of the patients with Meniere′s disease was significant low. It implied that DRB1*09 may be a protective gene for Meniere′s disease.