CAJ | 학술논문

目的观察奥美拉唑联合莫沙必利缓解胃食管反流症状和治疗反流性食管炎的疗效.方法 106例反流性食管炎病人,其中治疗组36例用奥美拉唑和莫沙必利,对照l组35例用奥美拉唑;对照2组35例用莫沙必利,观察治疗前及治疗后2、4、8周的临床症状改善和治疗8周的内镜变化.结果用药2周、4周时,治疗组症状好转与对照组相比,差异有统计学意义(P<0.05),用药8周结束时,治疗组症状改善明显优于对照组1和2组(P<0.05),内镜8周复查治疗组、对照组1和2组食管粘膜病损愈合率分别为86.1%、62.9%和57.1%,差异有统计学意义(P<0.05).结论奥美拉唑和莫沙必利联合用药较单一用药治疗反流性食管类疗效更好.
목적 관찰오미랍서연합막사필리완해위식관반류증상화치료반류성식관염적료효.방법 106례반류성식관염병인,기중치료조36례용오미랍서화막사필리,대조l조35례용오미랍서;대조2조35례용막사필리,관찰치료전급치료후2、4、8주적림상증상개선화치료8주적내경변화.결과 용약2주、4주시,치료조증상호전여대조조상비,차이유통계학의의(P<0.05),용약8주결속시,치료조증상개선명현우우대조조1화2조(P<0.05),내경8주복사치료조、대조조1화2조식관점막병손유합솔분별위86.1%、62.9%화57.1%,차이유통계학의의(P<0.05).결론 오미랍서화막사필리연합용약교단일용약치료반류성식관류료효경호.
Objective To observe the curative effect that treating and mitigating reflux esophgitis with omeprajoh and mosapride. Methods one hundred and six patients were divided into three groups. The fwst group(36 case) were treated with omeprajole and mosaprid. The second group(35 sides) were treated with omeprajole. The third group(35 sides) were treated with mosapride. The change in symptom and endoscope before and after treatment were observed. Results After treated for two week and four week,the first group was better than second and third group. There was significant difference between first group and second group or third group(P<0.05). When eight week, the symptom had been improved obviously in first group(P< 0.05). Esophageal mucosa erosion was coalesce,the percentage was 86.1%, 62.9%,57.1%, there was significant difference(P < 0.05). Conclusion Omeprazole combined with mosapride is better in curing reflux esophagitis.