中国急救医学
中國急救醫學
중국급구의학
CHINESE JOURNAL OF CRITICAL CARE MEDICINE
2010年
4期
312-314
,共3页
血必净注射液%危重病%凝血功能障碍
血必淨註射液%危重病%凝血功能障礙
혈필정주사액%위중병%응혈공능장애
Xuebijing injection%Critical illness%Coagulation dysfunction
目的 探讨血必净注射液在有凝血功能障碍危重病患者中的临床应用价值.方法 将67例入住ICU有凝血功能障碍的危重病患者随机分为治疗组34例,对照组33例.两组患者均给予常规综合治疗,治疗组同时给予血必净注射液治疗7 d.治疗前后分别取静脉血,检测凝血功能相关指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和血小板计数(PLT)]及血浆降钙素原(PCT)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)浓度.结果 治疗组治疗前后PLT、PT、APTT、TT、FIB及CRP、IL-6、PCT、急性生理及慢性健康状况评分Ⅱ(APACHEⅡ)比较差异均有统计学意义(P<0.05);治疗后两组PLT、PT、FIB及IL-6、PCT、APACHEⅡ评分比较差异均有统计学意义(P<0.05).结论 血必净注射液可以明显改善危重病患者的凝血功能障碍,减少炎症因子的生成,具有很高的临床应用价值.
目的 探討血必淨註射液在有凝血功能障礙危重病患者中的臨床應用價值.方法 將67例入住ICU有凝血功能障礙的危重病患者隨機分為治療組34例,對照組33例.兩組患者均給予常規綜閤治療,治療組同時給予血必淨註射液治療7 d.治療前後分彆取靜脈血,檢測凝血功能相關指標[凝血酶原時間(PT)、凝血酶時間(TT)、活化部分凝血活酶時間(APTT)、纖維蛋白原(FIB)和血小闆計數(PLT)]及血漿降鈣素原(PCT)、白細胞介素-6(IL-6)、C-反應蛋白(CRP)濃度.結果 治療組治療前後PLT、PT、APTT、TT、FIB及CRP、IL-6、PCT、急性生理及慢性健康狀況評分Ⅱ(APACHEⅡ)比較差異均有統計學意義(P<0.05);治療後兩組PLT、PT、FIB及IL-6、PCT、APACHEⅡ評分比較差異均有統計學意義(P<0.05).結論 血必淨註射液可以明顯改善危重病患者的凝血功能障礙,減少炎癥因子的生成,具有很高的臨床應用價值.
목적 탐토혈필정주사액재유응혈공능장애위중병환자중적림상응용개치.방법 장67례입주ICU유응혈공능장애적위중병환자수궤분위치료조34례,대조조33례.량조환자균급여상규종합치료,치료조동시급여혈필정주사액치료7 d.치료전후분별취정맥혈,검측응혈공능상관지표[응혈매원시간(PT)、응혈매시간(TT)、활화부분응혈활매시간(APTT)、섬유단백원(FIB)화혈소판계수(PLT)]급혈장강개소원(PCT)、백세포개소-6(IL-6)、C-반응단백(CRP)농도.결과 치료조치료전후PLT、PT、APTT、TT、FIB급CRP、IL-6、PCT、급성생리급만성건강상황평분Ⅱ(APACHEⅡ)비교차이균유통계학의의(P<0.05);치료후량조PLT、PT、FIB급IL-6、PCT、APACHEⅡ평분비교차이균유통계학의의(P<0.05).결론 혈필정주사액가이명현개선위중병환자적응혈공능장애,감소염증인자적생성,구유흔고적림상응용개치.
To study the clinical value of Xuebijing injection in coagulation dysfunction of critical illness patients. Methods 67 patients admitted to the Intensive Care Unit were divided into treatment groups (Xuebijing injection therapy) with 34 cases, and control groups with 33 cases. Two groups were conventionally received regular treatment. At the same time, the treatment group was treated with Xuebijing injection for a week. The coagulation function indexes and the levels of plasma procalcitonin, C-reactive protein and interleukin-6 were measured pre- and post- treatment. Results After Xuebijing treatment for a week, in treatment group, there was significant difference in PLT, PT, APTT, TT, FIB and CRP, IL-6, PCT, APACHEⅡ between pre- and post- treatment(P﹤0.05).There were significant differences in PLT, PT, FIB and IL-6, PCT, APACHEⅡbetween two groups after the treatment(P﹤0.05). Conclusion Xuebijing injection could improve coagulation indexes in critical illness patients with coagulation dysfunction, reduce the generation of inflammatory factor, and have important clinical value in the treatment of critical illness patients.
