国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2010年
6期
561-562,564
,共3页
妊娠并发症%高血压%内皮生长因子%妊娠相关α血浆蛋白质%实验室技术和方法
妊娠併髮癥%高血壓%內皮生長因子%妊娠相關α血漿蛋白質%實驗室技術和方法
임신병발증%고혈압%내피생장인자%임신상관α혈장단백질%실험실기술화방법
pregnancy complications%hypertension%endothelial growth factors%pregnancy associated alpha plasma protein%Laboratory Techniques and Procedurespregnant induced hypertension syndrome(PIH)%VEGF%PAPP-A%D-dimers
目的 探讨妊娠高血压综合征(PIH)患者血管内皮生长因子(VEGF)、血清妊娠相关血浆蛋白-A(PAPP-A)、D-二聚体(D-D)和N-乙酰-β-D-氨基葡萄糖甙酶/肌酐(NAG/Cr)比值的变化及意义.方法 通过检测92例PIH患者和35例健康妊娠孕妇PAPP-A、VEGF、D-D和NAG/Cr的水平,分析其与PIH的关系.结果 妊娠高血压综合征患者VEGF水平显著低于健康对照组,差异有统计学意义(P<0.01),且随着病情的加重而显著降低,而PAPP-A、D-D、NAG/Cr水平显著高于健康对照组,差异有统计学意义(P<0.01);且随着病情加重PAPP-A、D-D、NAG/Cr水平显著增高.结论 VEGF、PAPP-A、D-D、NAG/Cr与PIH的发生、发展密切相关,动态监测其水平变化对于PIH患者的病情判断、临床治疗均有重要意义.
目的 探討妊娠高血壓綜閤徵(PIH)患者血管內皮生長因子(VEGF)、血清妊娠相關血漿蛋白-A(PAPP-A)、D-二聚體(D-D)和N-乙酰-β-D-氨基葡萄糖甙酶/肌酐(NAG/Cr)比值的變化及意義.方法 通過檢測92例PIH患者和35例健康妊娠孕婦PAPP-A、VEGF、D-D和NAG/Cr的水平,分析其與PIH的關繫.結果 妊娠高血壓綜閤徵患者VEGF水平顯著低于健康對照組,差異有統計學意義(P<0.01),且隨著病情的加重而顯著降低,而PAPP-A、D-D、NAG/Cr水平顯著高于健康對照組,差異有統計學意義(P<0.01);且隨著病情加重PAPP-A、D-D、NAG/Cr水平顯著增高.結論 VEGF、PAPP-A、D-D、NAG/Cr與PIH的髮生、髮展密切相關,動態鑑測其水平變化對于PIH患者的病情判斷、臨床治療均有重要意義.
목적 탐토임신고혈압종합정(PIH)환자혈관내피생장인자(VEGF)、혈청임신상관혈장단백-A(PAPP-A)、D-이취체(D-D)화N-을선-β-D-안기포도당대매/기항(NAG/Cr)비치적변화급의의.방법 통과검측92례PIH환자화35례건강임신잉부PAPP-A、VEGF、D-D화NAG/Cr적수평,분석기여PIH적관계.결과 임신고혈압종합정환자VEGF수평현저저우건강대조조,차이유통계학의의(P<0.01),차수착병정적가중이현저강저,이PAPP-A、D-D、NAG/Cr수평현저고우건강대조조,차이유통계학의의(P<0.01);차수착병정가중PAPP-A、D-D、NAG/Cr수평현저증고.결론 VEGF、PAPP-A、D-D、NAG/Cr여PIH적발생、발전밀절상관,동태감측기수평변화대우PIH환자적병정판단、림상치료균유중요의의.
Objective To study the clinical significance of changes of blood contents of vascular endothelial growth factors (VEGF).Pregnancy-associated plasma protein-A(PAPP-A),D-dimers(D-D)and Urinary N-acetyl-β-D-glucosaminidase/Creatinine (NAG/Cr)Ratio in patients with Pregnancy Induced Hypertension syndrome(PIH).Methods Serum VEGF and PAPP-A(with ELISA),plasma D-dimers(with biochemistry)and NAG/Cr(with velocity)contents were measured in 92 pregnant women with PIH and 35 controls.Results The serum VEGF contents in patients with PIH were significantly lower than those in controls(P<0.01)while PAPP-A,D-dimers and NAG/Cr contents were significantly higher(P<0.01).Those changes were especially marked in patients with advanced diseases.Conclusion Changes of blood contents of VEGF,PAPP-A D-dimers and Urinary NAG/Cr Ratio were closely related with the disease process of PIH.Determination of these changes was of clinical diagnostic as well as prognostic value.
