CAJ | 학술논문

目的探讨每日一次吸入噻托溴铵对稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)肺动态过度充气的影响.方法实验对象使用信封法COPD稳定期患者40例被随机分入治疗组(噻托溴铵,18 μg,1次/d)和对照组(未吸入噻托溴铵),在接受实验药物治疗的当天、治疗后的第48天及第56天分别进行肺功能测定,测定最大深吸气量(IC)和功能残气量(FRC)值各3次,取其最高值以供数据分析;用食道气囊法检测动态内源性呼气末正压(PEEPidyn),取8个连续呼吸计算结果的均值作为测定值,在接受实验药物治疗的当天、治疗后的第48天及第56天分别进行测定.结果随机分组的患者人口统计学和基线特征各项指标差异无统计学意义,有可比性;治疗开始两组FRC、IC、PEEPidyn值差异无统计学意义(P＞0.05),治疗第28天噻托溴铵组FRC、PEEPidyn值较治疗第0天及对照组下降,IC值增加.但差异无统计学意义(P＞0.05);治疗的第56天噻托溴铵组FRC、PEEPidyn值较治疗第0天及对照组进一步下降,IC值进一步增加,且差异有统计学意义(P＜0.01).结论每日一次吸入噻托溴铵一定疗程可一定程度改善稳定期重度COPD肺动态过度充气.
목적 탐토매일일차흡입새탁추안대은정기만성조새성폐질병(chronic obstructive pulmonary disease,COPD)폐동태과도충기적영향.방법 실험대상사용신봉법COPD은정기환자40례피수궤분입치료조(새탁추안,18 μg,1차/d)화대조조(미흡입새탁추안),재접수실험약물치료적당천、치료후적제48천급제56천분별진행폐공능측정,측정최대심흡기량(IC)화공능잔기량(FRC)치각3차,취기최고치이공수거분석;용식도기낭법검측동태내원성호기말정압(PEEPidyn),취8개련속호흡계산결과적균치작위측정치,재접수실험약물치료적당천、치료후적제48천급제56천분별진행측정.결과 수궤분조적환자인구통계학화기선특정각항지표차이무통계학의의,유가비성;치료개시량조FRC、IC、PEEPidyn치차이무통계학의의(P＞0.05),치료제28천새탁추안조FRC、PEEPidyn치교치료제0천급대조조하강,IC치증가.단차이무통계학의의(P＞0.05);치료적제56천새탁추안조FRC、PEEPidyn치교치료제0천급대조조진일보하강,IC치진일보증가,차차이유통계학의의(P＜0.01).결론 매일일차흡입새탁추안일정료정가일정정도개선은정기중도COPD폐동태과도충기.
Objective To test the effects of tiotropium once daily on lung hyperinflation in patients with chronic obstructive pulmonary disease(COPD).Methods Forty stable COPD patients were randomized into two groups:20 patients(treatmen group)receive 18μg tiotropium once daily for 56 days,and control group(20 patients).On day 0,48,56 inspiratory capacity(IC)and functional residual capacity(FRC)were measured and compared,at the same time,dynamic intrinsic PEEP(PEEPidyn)were measured by using esophageal balloon-fipped catheter technique,respectively.Results There were no significant difference in IC,FRC,PEEPidyn between two groups(all P>0.05).On day 56,the changes continuously and have significant differences.Conclusions The use of tiotropium once daily for 56 days could obviously decrease the lung hyperinflation of stable COPD.