CAJ | 학술논문

PIK3CA基因编码蛋白激酶PI3K的p100α亚单位,参与PI3K的合成,通过下游PI3K/AKT通路发挥其生物学效应.多种肿瘤组织中可检测到PIK3CA基因突变,突变的PIK3CA异常激活PI3K-AKT信号通路,导致细胞周期异常、细胞黏附性下降、细胞凋亡下调及新生血管形成等,促进肿瘤发生发展.研究表明PIK3CA与结直肠癌的发生、发展、分化、转移及耐药密切相关,有望在结直肠癌的早期诊断、基因筛查、治疗方案制定、复发随访等方面提供一定的临床证据.
PIK3CA기인편마단백격매PI3K적p100α아단위,삼여PI3K적합성,통과하유PI3K/AKT통로발휘기생물학효응.다충종류조직중가검측도PIK3CA기인돌변,돌변적PIK3CA이상격활PI3K-AKT신호통로,도치세포주기이상、세포점부성하강、세포조망하조급신생혈관형성등,촉진종류발생발전.연구표명PIK3CA여결직장암적발생、발전、분화、전이급내약밀절상관,유망재결직장암적조기진단、기인사사、치료방안제정、복발수방등방면제공일정적림상증거.
The PIK3CA gene codes p100α,the catalytic subunit of phosphatidylinositol 3-kinase (PI3K) and is involved in the initiating the PI3K/AKT pathway.PIK3CA plays its biological roles through.downstream PI3K pathway. PIK3CA gene mutants can be detected in many kinds of tumors. The mutant PIK3CA gene can abnormally activate PI3K pathway,leading to the abnormal cell cycle,decreased cell adhesion,down regulated apoptosis and neovascularization,and then promotes tumor genesis and development.Recent researches have found that mutant PIK3CA gene is closely correlated with the genesis,development,differentiation,metastasis and drug resistance of colorectal cancer.Research of PIK3CA in colorectal cancer may provide significant evidence for the early diagnosis,gene screen,therapeutic regimen making,recurrence and follow up.