国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2011年
6期
348-351
,共4页
TRIB3基因%单核苷酸多态性%2型糖尿病
TRIB3基因%單覈苷痠多態性%2型糖尿病
TRIB3기인%단핵감산다태성%2형당뇨병
TRIB3%Single nucleotide polymorphism%Type 2 diabetes mellitus
TRIB3基因是2型糖尿病及糖尿病动脉粥样硬化的易感基因之一,其基因多态性Q84R与2型糖尿病有强相关性,这一结果在白种人中已得到证实.TRI3基因位于人染色体20p13-p12.2,蛋白质位称TRB3,该基因通过抑制丝氨酸/苏氨酸蛋白激酶Akt的磷酸化,抑制胰岛素信号传导,而在糖代谢中起重要作用.另外,有研究认为TRIB3基因可能调节胰腺β细胞功能.
TRIB3基因是2型糖尿病及糖尿病動脈粥樣硬化的易感基因之一,其基因多態性Q84R與2型糖尿病有彊相關性,這一結果在白種人中已得到證實.TRI3基因位于人染色體20p13-p12.2,蛋白質位稱TRB3,該基因通過抑製絲氨痠/囌氨痠蛋白激酶Akt的燐痠化,抑製胰島素信號傳導,而在糖代謝中起重要作用.另外,有研究認為TRIB3基因可能調節胰腺β細胞功能.
TRIB3기인시2형당뇨병급당뇨병동맥죽양경화적역감기인지일,기기인다태성Q84R여2형당뇨병유강상관성,저일결과재백충인중이득도증실.TRI3기인위우인염색체20p13-p12.2,단백질위칭TRB3,해기인통과억제사안산/소안산단백격매Akt적린산화,억제이도소신호전도,이재당대사중기중요작용.령외,유연구인위TRIB3기인가능조절이선β세포공능.
By far the most spectacular development in the field of multifactorial type 2 diabetes genetics has been the identification of Tribbles homolog 3-Drosophila( TRIB3 ).It is one of the most important susceptibility gene of type 2 diabetes and atherosclerosis with diabetes.Common variants in the gene that encodes Q84R have been strongly associated with type 2 diabetes.The result has been proved in white groups,but the study of TRIB3 Q84R is just started in China.The TRIB3 gene is on chromosome 20p12.2-p13 and encodes protein TRB3.The gene plays an important role in glucose metabolism by suppressing the phosphorylation of serine-threonine kinase and the conduction of insulin signals.In addition,TRIB3 may regulate the function of pancreas β-cells.
