CAJ | 학술논문

Rab蛋白家族是一类Ras相关的GTP结合蛋白,在细胞中发挥确保囊泡转运特异性定位的作用.作为Rab家族的一员,Rab7与其他的Rab成员间既有相似性,又有特异性.其相似性表现在:Rab7与其他的Rab成员有着相似的结构、相似的异戊二烯化过程以及相似的GDP/GTP结合功能;特异性表现在:Rab7特异识别晚期胞内体等囊泡,介导晚期胞内体与溶酶体的膜融合以完成溶酶体转运,发挥特有的生物学功能.Rab7蛋白的功能缺陷和多种人类遗传疾病相关.
Rab단백가족시일류Ras상관적GTP결합단백,재세포중발휘학보낭포전운특이성정위적작용.작위Rab가족적일원,Rab7여기타적Rab성원간기유상사성,우유특이성.기상사성표현재:Rab7여기타적Rab성원유착상사적결구、상사적이무이희화과정이급상사적GDP/GTP결합공능;특이성표현재:Rab7특이식별만기포내체등낭포,개도만기포내체여용매체적막융합이완성용매체전운,발휘특유적생물학공능.Rab7단백적공능결함화다충인류유전질병상관.
Rab protein family is a class of Ras related GTP-binding proteins.Rab proteins play important roles in vesicle transportation.As a number of this family,Rab7 has a comparability with other nabs in structures,islprenylation processing,and GDP/GTP-binding ability with a speciality in identification of late endosome.Interruption of Rab7 functions may result in several human genetic diseases.