国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
6期
428-430
,共3页
肺结核%甘露糖结合凝集素
肺結覈%甘露糖結閤凝集素
폐결핵%감로당결합응집소
Tuberculosis%Mannose-binding lectin
目的 分析广西壮族人群甘露糖结合凝集素(MBL)基因外显子1多态性,探讨其与肺结核的易感性关系.方法 采用聚合酶链反应-限制性片段长度多态性分析对100名健康壮族正常人和100例壮族肺结核患者的MBL基因外显子1多态性进行分析,分析两组间突变基因型频率的差异.结果 正常对照组与结核病组MBL突变等位基因(B等位基因)频率分别为33.3%和35.1%,两者差异无统计学意义.结论 MBL基因54密码子位点突变可能不是广西壮族人群肺结核病发病的遗传学危险因素.
目的 分析廣西壯族人群甘露糖結閤凝集素(MBL)基因外顯子1多態性,探討其與肺結覈的易感性關繫.方法 採用聚閤酶鏈反應-限製性片段長度多態性分析對100名健康壯族正常人和100例壯族肺結覈患者的MBL基因外顯子1多態性進行分析,分析兩組間突變基因型頻率的差異.結果 正常對照組與結覈病組MBL突變等位基因(B等位基因)頻率分彆為33.3%和35.1%,兩者差異無統計學意義.結論 MBL基因54密碼子位點突變可能不是廣西壯族人群肺結覈病髮病的遺傳學危險因素.
목적 분석엄서장족인군감로당결합응집소(MBL)기인외현자1다태성,탐토기여폐결핵적역감성관계.방법 채용취합매련반응-한제성편단장도다태성분석대100명건강장족정상인화100례장족폐결핵환자적MBL기인외현자1다태성진행분석,분석량조간돌변기인형빈솔적차이.결과 정상대조조여결핵병조MBL돌변등위기인(B등위기인)빈솔분별위33.3%화35.1%,량자차이무통계학의의.결론 MBL기인54밀마자위점돌변가능불시엄서장족인군폐결핵병발병적유전학위험인소.
Objective To analyze the polymorphism of exon 1 in mannose-binding lectin (MBL)gene in Zhuang population in Guangxi and to explore its relationship with the susceptibility to tuberculosis. Methods The polymorphism of exon 1 in MBL gene in 100 healthy individuals and 100 patients with tuberculosis was determined by polymerase chain reaction-restriction fragment length polymorphism to analyze the differences of mutant genotype frequency in two groups. Results There was no statistical significance on the frequency of MBL mutant allele (B allele) between healthy control group (33.3 % ) and tuberculosis group (35.1% ). Conclusions Mutation of codon 54 in MBL gene may not be the genetic risk factor of tuberculosis in Zhuang population in Guangxi.
