CAJ | 학술논문

目的探讨辛伐他汀治疗对2型糖尿患者尿白蛋白排泄率的影响.方法血压正常、血糖控制稳定的伴高胆固醇血症和白蛋白尿的2型糖尿患者25例,给予辛伐他汀20 mg/d,共三个月.于治疗前后测定空腹血糖、糖化血红蛋白、肌酐、尿素氮、内生肌酐清除牢、血脂、血压及尿白蛋白排泄率.结果辛伐他汀治疗前后患者的空腹mL糖、糖化血红蛋白、肌酐、尿素氮、内生肌酐清除率、血压、血清甘油三酯和高密度脂蛋白胆同醇的变化无统计学意义(P>0.05),治疗后血清总胆同醇、低密度脂蛋白和尿白蛋白排泄率降低(P<0.01).结论辛伐他汀治疗可降低高胆固醇血症的Z型糖尿患者尿白蛋白排泄率,提示他汀类调脂药对糖尿病肾病可能具有肾保护作用.
목적 탐토신벌타정치료대2형당뇨환자뇨백단백배설솔적영향.방법 혈압정상、혈당공제은정적반고담고순혈증화백단백뇨적2형당뇨환자25례,급여신벌타정20 mg/d,공삼개월.우치료전후측정공복혈당、당화혈홍단백、기항、뇨소담、내생기항청제뢰、혈지、혈압급뇨백단백배설솔.결과 신벌타정치료전후환자적공복mL당、당화혈홍단백、기항、뇨소담、내생기항청제솔、혈압、혈청감유삼지화고밀도지단백담동순적변화무통계학의의(P>0.05),치료후혈청총담동순、저밀도지단백화뇨백단백배설솔강저(P<0.01).결론 신벌타정치료가강저고담고순혈증적Z형당뇨환자뇨백단백배설솔,제시타정류조지약대당뇨병신병가능구유신보호작용.
Objective To investigate the effects of simvastatin on urinary albumin excretion rate in pa-tients With type 2 diabetes. Methods A total of 25 normotensive hypercholesterolemic type 2 diabetic patients with microalbuminurea or macroalbuminurea were enrolled in a study for 3 months,receiving Simvastatin at dose of 20 mg/day. Fasting plasma glucose, HbA 1c, systolic blood pressure, diastolic blood pressure, blood lipid, urea nitrogen,creatinine,endogenous creatinine clearance rate and urinary albumin excretion rate were obtained be-fore and after simvastatin treatment. Results Fasting plasma glucose, HbA1 c, systolic blood pressure, diastolic blood pressure, blood tiglyceride, HDL-cholesterol, urea nityogen, creatinine and endogenous creatitine clearance rate remained unchanged after simvastatin treatment(P＞0.05). Simvastatin significantly decreased plasma total cholesterol and LDL-cholesterol after 3 months of treatment (P<0.01). A concomitant significant decrease of urinary albumin excretion rate was observed during the same period (P<0.01). Conclusion Simvastatin de-creased urinary albumin excretion rate in type 2 diabetic patients with hypereholesterolemia,and statins appears to confer renoprotection in diabetes.