CAJ | 학술논문

近年来,通过RNA干扰技术在果蝇细胞中鉴定出钙离子释放激活钙通道(Ca2+ releaseactivated calcium channel,CRAC)的2种重要组成蛋白,即位于内质网上的Ca2+感受器间质相互作用分子1(stromal interaction molecule 1,STIM1)和位于细胞膜上的CRAC通道蛋白Orai1.研究表明,STIM1和Orai1对血管平滑肌细胞、血小板、血管内皮细胞等多种细胞均有调控作用,在血管平滑肌细胞表型转化、止血、血栓形成、新生血管发生等方面发挥着重要作用,显示两者可能与缺血性脑血管病密切相关.文章就STIM1和Orai1蛋白在缺血性脑血管病方面的研究进展进行了综述,以探讨STIM1和Orai1作为防治缺血性脑血管病的新靶点的可能性.
근년래,통과RNA간우기술재과승세포중감정출개리자석방격활개통도(Ca2+ releaseactivated calcium channel,CRAC)적2충중요조성단백,즉위우내질망상적Ca2+감수기간질상호작용분자1(stromal interaction molecule 1,STIM1)화위우세포막상적CRAC통도단백Orai1.연구표명,STIM1화Orai1대혈관평활기세포、혈소판、혈관내피세포등다충세포균유조공작용,재혈관평활기세포표형전화、지혈、혈전형성、신생혈관발생등방면발휘착중요작용,현시량자가능여결혈성뇌혈관병밀절상관.문장취STIM1화Orai1단백재결혈성뇌혈관병방면적연구진전진행료종술,이탐토STIM1화Orai1작위방치결혈성뇌혈관병적신파점적가능성.
In recent years,two important component proteins of the calcium release-activated calcium channel (CRAC) were identified from Drosophila cells by RNA interference technique,including the calcitum sensor stromal interaction molecule 1 (STIM1) on the endoplasmic reticulum and the CRAC channel protein Orail on the cell membrane.Studies have shown that STIM 1 and Orail have regulatory effects on vascular smooth muscle cells,platelets,vascular endothelial cells and other cells.They play important roles in the aspects of vascular smooth muscle cell phenotypic modulation,hemostasis,thrombosis,and neovascularization.It shows that they both may be closely associated with ischemic cerebrovascular disease.This article reviews the advances in research on STIM1 and Orail proteins in ischemic cerebrovascular disease in order to investigate the possibility of STIM1/Orai1 as a new target in the prevention and treatment of ischemic cerebrovascular