国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2009年
2期
100-103
,共4页
CD4+CD25+调节性T细胞%Foxp3%肿瘤免疫%预后%治疗
CD4+CD25+調節性T細胞%Foxp3%腫瘤免疫%預後%治療
CD4+CD25+조절성T세포%Foxp3%종류면역%예후%치료
CD4+ CD25+ regulatory T cell%Foxp3%Tumor immunology%Prognosis%Treatment
CD4+CD25+调节性T细胞是一类具有免疫抑制功能的T细胞亚群,能阻止肿瘤免疫和逃避肿瘤对抗原的有效识别.Foxp3是近年来发现的一种转录因子,是CD4+CD25+调节性T细胞表面特异性标志,检测其表达可以作为判定CD4+CD25+调节性T细胞的方法.最近,大量研究已经证实CD4+CD25+调节性T细胞与各种肿瘤生存期和不良预后密切相关.目前,CD4+CD25+调节性T细胞的靶向治疗和选择性清除成为新的免疫治疗方法.
CD4+CD25+調節性T細胞是一類具有免疫抑製功能的T細胞亞群,能阻止腫瘤免疫和逃避腫瘤對抗原的有效識彆.Foxp3是近年來髮現的一種轉錄因子,是CD4+CD25+調節性T細胞錶麵特異性標誌,檢測其錶達可以作為判定CD4+CD25+調節性T細胞的方法.最近,大量研究已經證實CD4+CD25+調節性T細胞與各種腫瘤生存期和不良預後密切相關.目前,CD4+CD25+調節性T細胞的靶嚮治療和選擇性清除成為新的免疫治療方法.
CD4+CD25+조절성T세포시일류구유면역억제공능적T세포아군,능조지종류면역화도피종류대항원적유효식별.Foxp3시근년래발현적일충전록인자,시CD4+CD25+조절성T세포표면특이성표지,검측기표체가이작위판정CD4+CD25+조절성T세포적방법.최근,대량연구이경증실CD4+CD25+조절성T세포여각충종류생존기화불량예후밀절상관.목전,CD4+CD25+조절성T세포적파향치료화선택성청제성위신적면역치료방법.
CD4+CD25+ regulatory T cells is a subset with acknowledged specific function of inhibiting immune responses. CD4+ CD25+ regulatory T cells have been associated with prevention of anti-tumor immunity and the evasion of efficient recognition of tumor antigens. Transcription factor forkhead box protein 3 (Foxp3) has been identified as a marker of CD4+CD25+ regulatory T cells. The expression of Foxp3 could be used to identify regulatory T cell. Recently,a lot of studies have certified that a number of CD4+CD25+ regulatory T cells arc described to be associated with poor survival and prognosis in different malignancies. Treatments have been developed to target and deplete CD4+CD25+ regulatory T cells in the context of tumors.
