中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
4期
436-438
,共3页
汪永忠%夏伦祝%冯艺戎%陈莉%孟楣
汪永忠%夏倫祝%馮藝戎%陳莉%孟楣
왕영충%하륜축%풍예융%진리%맹미
重连口服液%提取工艺%正交试验%重楼皂苷Ⅰ%连翘苷
重連口服液%提取工藝%正交試驗%重樓皂苷Ⅰ%連翹苷
중련구복액%제취공예%정교시험%중루조감Ⅰ%련교감
Chonglian oral solution%Extraction technology%Orthogonal test%Pariphyllin Ⅰ%Phillyrin
目的 优选重连口服液最佳提取工艺.方法 水提取工艺以浸膏得率、重楼皂苷Ⅰ和连翘苷的含量为考察指标,醇沉工艺以重楼皂苷Ⅰ和连翘苷的含量为考察指标,分别采用正交试验法对其提取工艺条件进行优选.结果 重连口服液水提最佳工艺条件为加水煎煮3次,每次10倍量水,煎煮1 h,醇沉最佳工艺条件为浓缩至相对密度1.10(80 ℃热测),加乙醇使药液乙醇浓度达到80%,静置24 h.结论 优选的提取工艺合理,稳定性好,可为工业生产提供理论依据.
目的 優選重連口服液最佳提取工藝.方法 水提取工藝以浸膏得率、重樓皂苷Ⅰ和連翹苷的含量為攷察指標,醇沉工藝以重樓皂苷Ⅰ和連翹苷的含量為攷察指標,分彆採用正交試驗法對其提取工藝條件進行優選.結果 重連口服液水提最佳工藝條件為加水煎煮3次,每次10倍量水,煎煮1 h,醇沉最佳工藝條件為濃縮至相對密度1.10(80 ℃熱測),加乙醇使藥液乙醇濃度達到80%,靜置24 h.結論 優選的提取工藝閤理,穩定性好,可為工業生產提供理論依據.
목적 우선중련구복액최가제취공예.방법 수제취공예이침고득솔、중루조감Ⅰ화련교감적함량위고찰지표,순침공예이중루조감Ⅰ화련교감적함량위고찰지표,분별채용정교시험법대기제취공예조건진행우선.결과 중련구복액수제최가공예조건위가수전자3차,매차10배량수,전자1 h,순침최가공예조건위농축지상대밀도1.10(80 ℃열측),가을순사약액을순농도체도80%,정치24 h.결론 우선적제취공예합리,은정성호,가위공업생산제공이론의거.
Objective To optimize Chonglian oral solution extracting craft. Methods With the obtaining rate of extract and the total content of the Pariphyllin Ⅰ and Phillyrin presented in the extract as the indexes for the water extraction process,and with the total content of the Pariphyllin Ⅰ and Phillyrin presented in the extract as the indexes for the alcohol deposition process,orthogonal design was used to optimize the conditions for the extraction process respectively. Results The optimal conditions for the water extraction of Chonglian oral solution was as following:to add water 10 times,decocting 3 times,1 hour each time.The optimal conditions for the alcohol deposition of Chonglian oral solution was as following:concentrated for the relative density to 1.10(80C hot test),cold,add ethanol to the solution for the ethanol content of the solution reached 80%,static settlement for 24 hours. Conclusion The extracting method is reasonable,stable,and suitable to industrialized producting.