中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
9期
1079-1080
,共2页
胸腔积液,恶性%胸膜腔引流术%复方苦参注射液%顺铂
胸腔積液,噁性%胸膜腔引流術%複方苦參註射液%順鉑
흉강적액,악성%흉막강인류술%복방고삼주사액%순박
Pleural effusion,malignant%Drainage of pleural cavity%Compound kushen injection%Cisplatin
目的 探讨胸腔置管引流术并腔内灌注复方苦参注射液联合顺铂治疗恶性胸腔积液的近期疗效与不良反应.方法 经病理学或细胞学确诊为恶性胸腔积液患者共78例,按入院先后顺序随机分为观察组与对照组,每组各39例.在充分引流胸腔积液后,观察组胸腔内注入复方苦参注射液25 ml+顺铂40 ～60 mg,对照组胸腔注入顺铂40 ～60 mg,2组均每周1次,共计4次,观察疗效、生活质量及不良反应.结果 观察组与对照组总有效率分别为84.6％(33/39)和59.0％( 23/39),组间比较差异有统计学意义(P＜0.05).观察组用药后生活质量改善明显,卡氏评分提高,改善率为74.4％( 29/39),明显高于对照组的46.1％ (18/39),组间比较差异有统计学意义(P＜0.05).观察组各种不良反应发生率均低于对照组,组间比较差异有统计学意义(P＜0.05).结论 胸腔置管引流并腔内灌注复方苦参注射液和顺铂治疗恶性胸腔积液疗效优于单用顺铂,且可提高患者生活质量、减少不良反应的发生.
目的 探討胸腔置管引流術併腔內灌註複方苦參註射液聯閤順鉑治療噁性胸腔積液的近期療效與不良反應.方法 經病理學或細胞學確診為噁性胸腔積液患者共78例,按入院先後順序隨機分為觀察組與對照組,每組各39例.在充分引流胸腔積液後,觀察組胸腔內註入複方苦參註射液25 ml+順鉑40 ～60 mg,對照組胸腔註入順鉑40 ～60 mg,2組均每週1次,共計4次,觀察療效、生活質量及不良反應.結果 觀察組與對照組總有效率分彆為84.6％(33/39)和59.0％( 23/39),組間比較差異有統計學意義(P＜0.05).觀察組用藥後生活質量改善明顯,卡氏評分提高,改善率為74.4％( 29/39),明顯高于對照組的46.1％ (18/39),組間比較差異有統計學意義(P＜0.05).觀察組各種不良反應髮生率均低于對照組,組間比較差異有統計學意義(P＜0.05).結論 胸腔置管引流併腔內灌註複方苦參註射液和順鉑治療噁性胸腔積液療效優于單用順鉑,且可提高患者生活質量、減少不良反應的髮生.
목적 탐토흉강치관인류술병강내관주복방고삼주사액연합순박치료악성흉강적액적근기료효여불량반응.방법 경병이학혹세포학학진위악성흉강적액환자공78례,안입원선후순서수궤분위관찰조여대조조,매조각39례.재충분인류흉강적액후,관찰조흉강내주입복방고삼주사액25 ml+순박40 ～60 mg,대조조흉강주입순박40 ～60 mg,2조균매주1차,공계4차,관찰료효、생활질량급불량반응.결과 관찰조여대조조총유효솔분별위84.6％(33/39)화59.0％( 23/39),조간비교차이유통계학의의(P＜0.05).관찰조용약후생활질량개선명현,잡씨평분제고,개선솔위74.4％( 29/39),명현고우대조조적46.1％ (18/39),조간비교차이유통계학의의(P＜0.05).관찰조각충불량반응발생솔균저우대조조,조간비교차이유통계학의의(P＜0.05).결론 흉강치관인류병강내관주복방고삼주사액화순박치료악성흉강적액료효우우단용순박,차가제고환자생활질량、감소불량반응적발생.
Objective To investigate the recent curative and side effects of using compound kushen injection and cisplatin as pleura] infusion for malignant pleura] effusion.Methods Seventy-eight patients who were diagnosed of malignant pleural effusion based on pathology and cytology were divided into two groups randomly.Observation group:compound kushen injection 25 ml +0.9％ sodium chloride injection 40 ml + cisplatin 40-60 ml were injected into thoracic cavity after adequate drainage.Control group:0.9％ sodium chlorideinjection 40 ml +cisplatin 40-60 ml were injected into thoracic cavity after adequate drainage.The curative effects,quality of life and side effects were recorded.Results In the observation group,14 patients were complete remission,19 patients were partial remission and 6 patients had no response.The total response rate was 84.6％ (33/39).In the control group,11 patients were complete remission,12 patients were partial remission and 16 patients had no response.The total response rate was 59.0％ (23/39).The total response rate in the observation group was obviously higher than that in the control group (P＜0.05).The improvement of quality of life in observation group [74.4％ (29/39)]was obviously higher than in the control group [ 46.1％ (18/39)] (P＜0.05 ).The incidence rate of side effects in observation group was much lower than that in the control group (P＜0.05 ).Conclusions For malignant pleural effusion,using compound kushen injection with cisplatin as pleural infusion is better than using cisplatin only.It can also improve the patients'quality of life and prevent the incidence of the side effects.
