中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2009年
1期
10-12
,共3页
罗国春%梁真%呼庆红%阎德文%吕凌波%顾文惠%陈泽龙%李海燕%刘明铭
囉國春%樑真%呼慶紅%閻德文%呂凌波%顧文惠%陳澤龍%李海燕%劉明銘
라국춘%량진%호경홍%염덕문%려릉파%고문혜%진택룡%리해연%류명명
糖尿病,1型%胰岛素抗药性%高胰岛素正葡萄糖钳夹技术
糖尿病,1型%胰島素抗藥性%高胰島素正葡萄糖鉗夾技術
당뇨병,1형%이도소항약성%고이도소정포도당겸협기술
Diabetes mellitus,type 1%Insulin resistance%Euglycemic-hyperinsulinemic clamp technique
目的 应用高胰岛素正葡萄糖钳夹技术评价1 型糖尿病(T1DM)患者胰岛素抵抗程度.方法 选择新诊断T1DM患者8例,初诊未治2型糖尿病(T2DM)患者8例,均经2周胰岛素强化治疗后进行高胰岛素正葡萄糖钳夹检测胰岛素敏感性指数(ISI),并与正常糖耐量志愿者10例进行比较.结果 T1DM组的年龄、BMI、空腹胰岛素(FIns)及空腹C-肽等各项参数显著低于正常对照组(P＜0.05),而腰臀比(WHR)、收缩压(SBP)、舒张压(DBP)、TC、TG、LDI-C、HDL-C均与正常对照组差异无统计学意义.T1DM组与T2DM组比较,年龄、BMI、WHR、FIns、空腹C-肽、SBP、TC、TG均显著低于T2DM组(P＜0.05).正常对照组、T1DM组、T2DM组ISI分别为12.83±1.09、9.95±0.50、3.80±0.20,3组间ISI差异有统计学意义(P＜0.05).结论 高胰岛素正葡萄糖钳夹检测结果显示,TIDM患者的ISI显著低于正常人,但高于T2DM患者.
目的 應用高胰島素正葡萄糖鉗夾技術評價1 型糖尿病(T1DM)患者胰島素牴抗程度.方法 選擇新診斷T1DM患者8例,初診未治2型糖尿病(T2DM)患者8例,均經2週胰島素彊化治療後進行高胰島素正葡萄糖鉗夾檢測胰島素敏感性指數(ISI),併與正常糖耐量誌願者10例進行比較.結果 T1DM組的年齡、BMI、空腹胰島素(FIns)及空腹C-肽等各項參數顯著低于正常對照組(P＜0.05),而腰臀比(WHR)、收縮壓(SBP)、舒張壓(DBP)、TC、TG、LDI-C、HDL-C均與正常對照組差異無統計學意義.T1DM組與T2DM組比較,年齡、BMI、WHR、FIns、空腹C-肽、SBP、TC、TG均顯著低于T2DM組(P＜0.05).正常對照組、T1DM組、T2DM組ISI分彆為12.83±1.09、9.95±0.50、3.80±0.20,3組間ISI差異有統計學意義(P＜0.05).結論 高胰島素正葡萄糖鉗夾檢測結果顯示,TIDM患者的ISI顯著低于正常人,但高于T2DM患者.
목적 응용고이도소정포도당겸협기술평개1 형당뇨병(T1DM)환자이도소저항정도.방법 선택신진단T1DM환자8례,초진미치2형당뇨병(T2DM)환자8례,균경2주이도소강화치료후진행고이도소정포도당겸협검측이도소민감성지수(ISI),병여정상당내량지원자10례진행비교.결과 T1DM조적년령、BMI、공복이도소(FIns)급공복C-태등각항삼수현저저우정상대조조(P＜0.05),이요둔비(WHR)、수축압(SBP)、서장압(DBP)、TC、TG、LDI-C、HDL-C균여정상대조조차이무통계학의의.T1DM조여T2DM조비교,년령、BMI、WHR、FIns、공복C-태、SBP、TC、TG균현저저우T2DM조(P＜0.05).정상대조조、T1DM조、T2DM조ISI분별위12.83±1.09、9.95±0.50、3.80±0.20,3조간ISI차이유통계학의의(P＜0.05).결론 고이도소정포도당겸협검측결과현시,TIDM환자적ISI현저저우정상인,단고우T2DM환자.
Objective To investigate insulin resistance in type 1 diabetes(T1DM)with euglycemic-hyperinsulinemic clamp.Methods Eight cases of newly diagnosed T1DM and 8 cases of newly diagnosed type 2 diabetes(T2DM)were selected.Their insulin sensitivity index(ISI)was evaluated with euglycemic-hyperinsulinemic clamp after 2 week insulin intensive treatment and compared with that of 10 heMthy volunteers(normal control group,NC group).Results Age,BMI,fasting insulin(Fins),fasting C-peptide in the TI DM group were significantly lower than those in the NC group.while waist-to-hip ratio (WHR),systolic blood pressure(SBP),diastolic blood pressure(DBP),TC,TG,LDL-C,HDL-C were not significantly different between the T1DM and NC groups.Age,BMI,WHR,Fins,fasting C-peptide,SBP,TC,TG in the T1DM group were significantly lower than those in the T2DM group.The ISI of the NC,TlDM and T2DM groups were 12.83±1.09,9.95±0.50,3.80±0.20,respectively.There was significant difference among the three groups(P＜0.05).Conclusion The ISI in T1DM Was significantly lower than that in NC group,but higher than that in T2DM.
