中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
10期
836-838
,共3页
郭如雅%顾爱明%干正琦%方立曙
郭如雅%顧愛明%榦正琦%方立曙
곽여아%고애명%간정기%방립서
糖尿病,2型%轻度认知功能损害%预防%治疗%尼莫地平
糖尿病,2型%輕度認知功能損害%預防%治療%尼莫地平
당뇨병,2형%경도인지공능손해%예방%치료%니막지평
Diabetes mellitus,type 2%Mild cognitive impairment%Prevention%Treatment%Nimodipine
以蒙特利尔认知评估量表(MoCA)、脑诱发电位失匹配负波(MMN)为工具选取98例2型糖尿病合并轻度认知功能损害患者.选择其中48例患者在常规治疗同时给予尼莫地平20 mg/d(用药组),观察与其他50例患者(对照组)18个月后MoCA、MMN的变化.两组间MoCA评分未见明显差异(P>0.05).用药组MMN的潜伏期、波幅较治疗前改善,差异有统计学意义(P<0.05);对照组MMN的波幅较治疗前进一步降低,差异有统计学意义(P<0.05),但MMN潜伏期治疗前后没有显著性差异(P>0.05).
以矇特利爾認知評估量錶(MoCA)、腦誘髮電位失匹配負波(MMN)為工具選取98例2型糖尿病閤併輕度認知功能損害患者.選擇其中48例患者在常規治療同時給予尼莫地平20 mg/d(用藥組),觀察與其他50例患者(對照組)18箇月後MoCA、MMN的變化.兩組間MoCA評分未見明顯差異(P>0.05).用藥組MMN的潛伏期、波幅較治療前改善,差異有統計學意義(P<0.05);對照組MMN的波幅較治療前進一步降低,差異有統計學意義(P<0.05),但MMN潛伏期治療前後沒有顯著性差異(P>0.05).
이몽특리이인지평고량표(MoCA)、뇌유발전위실필배부파(MMN)위공구선취98례2형당뇨병합병경도인지공능손해환자.선택기중48례환자재상규치료동시급여니막지평20 mg/d(용약조),관찰여기타50례환자(대조조)18개월후MoCA、MMN적변화.량조간MoCA평분미견명현차이(P>0.05).용약조MMN적잠복기、파폭교치료전개선,차이유통계학의의(P<0.05);대조조MMN적파폭교치료전진일보강저,차이유통계학의의(P<0.05),단MMN잠복기치료전후몰유현저성차이(P>0.05).
Ninty-eight patients of type 2 diabetes mellitus with mild cognitive impairment were collected according to the Montreal Cognitive Assessment( MoCA )and mismatch negativity( MMN ).Forty-eight patients were assigned to conventional treatment with nimodipine (20 mg/d).The MoCA and MMN were evaluated and compared with the remaining 50 patients who served as a control group.There was no significant difference between two patient groups in MoCA( P>0.05 ) ;the latency and amplitude of MMN were significantly improved in the treated group( P<0.05 ) ; the amplitude of MMN was reduced in control group ( P<0.05 ),but the latency of MMN showed no significant change( P>0.05 ).