CAJ | 학술논문

目的探讨原发性三叉神经痛(TN)合并根区蛛网膜粘连与HSV -1感染的关系.方法对TN患者于显微血管减压术中见其三叉神经根区合并蛛网膜粘连者59例,取其蛛网膜作为实验组；未合并根区明显蛛网膜粘连的TN患者24例,取其蛛网膜作为病例对照组；采用PCR和Western Blot方法分别检测其HSV -1特异性DNA片段、特异性抗原,并以20例外伤患者蛛网膜做正常对照.结果三组资料中DNA片段阳性率分别为:69％、58％和25％；实验组和病例对照组的DNA片段阳性率均高于正常对照组,且差异有统计学意义(P＜0.05),但实验组和病例对照组相比差异无统计学意义(P＞0.05)；病毒特异性抗原阳性率分别为:51％、25％和15％,实验组病毒抗原阳性率高于病例对照组,也高于正常对照组,差异有统计学意义(P＜0.05),而病例对照组和正常对照组相比差异无统计学意义(P＞0.05).结论 HSV -1病毒增殖性感染可能促使TN患者三叉神经根区蛛网膜的粘连,蛛网膜组织可能是HSV -1潜伏感染的另一基地；HSV -1病毒感染可能是TN又一致病因素.
목적 탐토원발성삼차신경통(TN)합병근구주망막점련여HSV -1감염적관계.방법 대TN환자우현미혈관감압술중견기삼차신경근구합병주망막점련자59례,취기주망막작위실험조；미합병근구명현주망막점련적TN환자24례,취기주망막작위병례대조조；채용PCR화Western Blot방법분별검측기HSV -1특이성DNA편단、특이성항원,병이20예외상환자주망막주정상대조.결과 삼조자료중DNA편단양성솔분별위:69％、58％화25％；실험조화병례대조조적DNA편단양성솔균고우정상대조조,차차이유통계학의의(P＜0.05),단실험조화병례대조조상비차이무통계학의의(P＞0.05)；병독특이성항원양성솔분별위:51％、25％화15％,실험조병독항원양성솔고우병례대조조,야고우정상대조조,차이유통계학의의(P＜0.05),이병례대조조화정상대조조상비차이무통계학의의(P＞0.05).결론 HSV -1병독증식성감염가능촉사TN환자삼차신경근구주망막적점련,주망막조직가능시HSV -1잠복감염적령일기지；HSV -1병독감염가능시TN우일치병인소.
Objective To assess the relationship that trigeminal neuralgia combining arachnoids' adhesions and herpes simplex virus type 1.Methods There are fifty nine patients with trigeminal neuralgia their trigeminal nerve root area combined arachnoids' adhesion,cutting their arachnoids as the experimental group.There are twenty four patients with trigeminal neuralgia their trigeminal nerve root area is not combined significant arachnoids' adhesion,cutting their arachnoids as the case -control group.Using polymerase chain reaction and Western blot technique to detecting the HSV - 1 specific DNA fragments and specific antigen,and cutting twenty arachnoids of the patients with Brain Trauma as the normal control group.Results The positive ratio of DNA fragments in the three group is 69％、58％ and 25％ respectively.The positive ratio of DNA fragments in the experiment group and case - control group were higher than the normal control group,with statistical difference( P ＜ 0.05 ),but the experimental group and case -control group compared with no significant difference( P ＞ 0.05 ).The positive ratio of virus - specific antigen is 51％、25％ and 15％ respectively.The positive ratio of virus - specific antigen was higher than the case - control group,also higher than the normal control group,were significantly different( P ＜ 0.05 ),while the case -control group and the normal control group compared with no significant differences ( P ＞ 0.05 ).Conclusion HSV - 1 proliferating infected patients with trigeminal neuralgia may result in the arachnoids adhesion of trigeminal nerve root zone; arachnoids tissue may be another latent base of HSV - 1 ; HSV - 1 infection may be another pathogenic factor of trigeminal neuralgia.