中国药学(英文版)
中國藥學(英文版)
중국약학(영문판)
JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES
2001年
3期
124-127
,共4页
RNA%构象%Tm
RNA%構象%Tm
RNA%구상%Tm
RNA%Conformation%Tm
本文对两种具有抗HIV-1活性的药物与RNA的相互作用进行了探讨.紫外Tm测定及CD光谱结果表明,两种药物均可与polyA@polyU相互作用,影响其构象的改变.流式细胞仪分析提示药物可不同程度地影响cos-7亚二倍体细胞含量,其中 ribavirin的作用更显著.
本文對兩種具有抗HIV-1活性的藥物與RNA的相互作用進行瞭探討.紫外Tm測定及CD光譜結果錶明,兩種藥物均可與polyA@polyU相互作用,影響其構象的改變.流式細胞儀分析提示藥物可不同程度地影響cos-7亞二倍體細胞含量,其中 ribavirin的作用更顯著.
본문대량충구유항HIV-1활성적약물여RNA적상호작용진행료탐토.자외Tm측정급CD광보결과표명,량충약물균가여polyA@polyU상호작용,영향기구상적개변.류식세포의분석제시약물가불동정도지영향cos-7아이배체세포함량,기중 ribavirin적작용경현저.
The aim of this study was to investigate the interaction between polymers polyA.polyU (RNA)and two general anti-viral drugs with anti-HIV-1 activities. Tm experiment showed that thc compounds had interacted with RNA,and CD spectra also observed the changes of RNA conformation induced by the compounds.Cytometric flow analysis indicated that ribavirin and DII-18-2 could decrease the percentage of hypodiploid cells,especially ribavirin.
