中国科学G辑(英文版)
中國科學G輯(英文版)
중국과학G집(영문판)
SCIENCE IN CHINA (PHYSICS ASTRONOMY)
2003年
6期
659-669
,共11页
刘赟%王宝翰%王存新%陈慰祖
劉赟%王寶翰%王存新%陳慰祖
류빈%왕보한%왕존신%진위조
protein design%relative entropy%off-lattice model
A new effective and fast minimization approach completely based on the physical theory is proposed for protein design. The sequence space is essentially searched according to the Boltzmann distribution. In this approach, the relative entropy is used as a minimization object function. The method has been tested on an off-lattice model of proteins and the results are better than those obtained from other similar work. Therefore, it can be applied as a uniform frame for both folding and inverse folding of proteins.
