CAJ | 학술논문

为进一步探讨ADPR的生物学功能,本文设计并合成了用天门冬氨酸二肽代替焦磷酸结构的一类新型ADPR类似物.通过以5'-氨基腺苷或其模拟物为起始原料,采用类似于液相肽的合成方法,成功地构建了四个目标分子,其结构经tH NMR、HRMS等进行了鉴定.本研究为新型ADPR类似物的合成提供了一条便利途径.
위진일보탐토ADPR적생물학공능,본문설계병합성료용천문동안산이태대체초린산결구적일류신형ADPR유사물.통과이5'-안기선감혹기모의물위기시원료,채용유사우액상태적합성방법,성공지구건료사개목표분자,기결구경tH NMR、HRMS등진행료감정.본연구위신형ADPR유사물적합성제공료일조편리도경.
For investigating the biological function of ADPR,four novel analogues(compounds 2-5)in which the pyrophosphate linkage was replaced by the aspartic acid dipeptide were synthesized.5'-Amino adenosine or its analogues was used as the starting material,liquid phase peptide synthesis strategy was used to construct these ADPR analogues.The structures were characterized by 1H NMR and HRMS spectra.This study provides a versatile synthesis of peptide modified ADPR analogues and helps to understand the structure-activity relationship of ADPR.