CAJ | 학술논문

乌头属植物是被子植物亚门毛茛科中一类重要的有毒植物,也是我国最早有记载的药用有毒植物之一;其块根中多含有剧毒的二萜类双酯型生物碱-乌头碱,因个体差异、用法不当以及误服或投毒等原因而发生乌头中毒、甚至死亡的报道屡见不鲜.目前,对乌头碱的研究多局限在临床救治方面,缺乏对乌头碱毒性作用机制研究.本文参考国内外相关文献资料,对乌头碱的心肌细胞毒性作用机制进行了综述.
오두속식물시피자식물아문모간과중일류중요적유독식물,야시아국최조유기재적약용유독식물지일;기괴근중다함유극독적이첩류쌍지형생물감-오두감,인개체차이、용법불당이급오복혹투독등원인이발생오두중독、심지사망적보도루견불선.목전,대오두감적연구다국한재림상구치방면,결핍대오두감독성작용궤제연구.본문삼고국내외상관문헌자료,대오두감적심기세포독성작용궤제진행료종술.
Aconltium plants are a group of important poisonous plants in the Ranunculaeeae family of Angiosperm subphylum.and one of the earliest recorded poisonous plants in China as well.In their tubers(root)have hypertoxic Aconitium alkaloids,which belong to the group of diesterditerpene alkaloids.It is repeatedly reported in China that aconitine poisoning,and even death from aconitine poisoning,caused by the individual differences in pharmaceutical tolerance of aconitine,taking the wrong medicine or inadequate dosage,or put in the poison by homicide.At present,the research on aconitine is mainly limited to clinical treatment,but lack of research on toxicity mechanism of aeonitine.This paper reviews some progress relating to the toxicological mechanisms of this kind of alkaloid.