CAJ | 학술논문

目的:通过基于磁共振图像的体积测量技术测量正常成人的纹状体体积,探讨国人纹状体随年龄退化的规律,以及男女两性和左右侧纹状体的体积差异.方法:年龄跨度在18至70岁的健康成人100例,运用磁共振快速扰相梯度回波序列获得全脑的高分辨率三维结构图像,使用Mricro软件在结构像上人工勾划尾状核和壳核的边界,计算出双侧尾状核和壳核的体积.结果:健康成人双侧尾状核体积为(8.42±0.88 )cm~3,两侧壳核体积为(8.90±0.89)cm~3.尾状核(r=-0.727,P<0.001)和壳核(r=-0.709,P<0.001)的体积均随着年龄的增长而缩小,平均每年缩小约0.52%和0.50%.男女性之间的尾状核和壳核体积均未发现显著差异.男性纹状体体积每年减少约0.55%,女性每年减少约0.48%.无论男性还是女性,左侧尾状核(t=4.43,P<0.001)和壳核(t=4.88,P<0.001)体积均较右侧大.结论:成人纹状体体积随着年龄增长而缩小.男女性之间的纹状体平均体积没有明显差异,但是男性纹状体较女性退化稍快.纹状体的体积分布存在左侧优势的特性,左侧纹状体体积比右侧大.
목적:통과기우자공진도상적체적측량기술측량정상성인적문상체체적,탐토국인문상체수년령퇴화적규률,이급남녀량성화좌우측문상체적체적차이.방법:년령과도재18지70세적건강성인100례,운용자공진쾌속우상제도회파서렬획득전뇌적고분변솔삼유결구도상,사용Mricro연건재결구상상인공구화미상핵화각핵적변계,계산출쌍측미상핵화각핵적체적.결과:건강성인쌍측미상핵체적위(8.42±0.88 )cm~3,량측각핵체적위(8.90±0.89)cm~3.미상핵(r=-0.727,P<0.001)화각핵(r=-0.709,P<0.001)적체적균수착년령적증장이축소,평균매년축소약0.52%화0.50%.남녀성지간적미상핵화각핵체적균미발현현저차이.남성문상체체적매년감소약0.55%,녀성매년감소약0.48%.무론남성환시녀성,좌측미상핵(t=4.43,P<0.001)화각핵(t=4.88,P<0.001)체적균교우측대.결론:성인문상체체적수착년령증장이축소.남녀성지간적문상체평균체적몰유명현차이,단시남성문상체교녀성퇴화초쾌.문상체적체적분포존재좌측우세적특성,좌측문상체체적비우측대.
Objective: To examine the age,sex,and hemispheric differences in volume of the striatum by MRI in healthy adults. Methods: The volumes of the bilateral caudate nucleus and putamen were measured on MR images in 100 healthy right-handed adults (18-70 y). Results: The volume of bilateral caudate nucleus and putamen in healthy adults was (8.42±0.88) cm~3 and (8.90±0.89) cm~3,which were decreased with aging (for caudate nucleus r=-0.727,P<0.001; for putamen r=-0.709,P<0.001).The average annual shrinkage rate was 0.52% in the caudate nucleus and 0.50% in the puatmen.There were no gender differences in the volume of the striatum,however,the age-related shrinkage of the striatum was more evident in men than that in women.The volume of the left caudate nucleus (t=4.43,P<0.001) and the putamen (t=4.88,P<0.001) was greater than that of its right counterpart. Conclusion: Bilateral age-related shrinkage of the striatum is found in healthy adults,which is more evident in men than that in women.In both sexes,significant leftward asymmetry in volume of the caudate nucleus and the putamen is found.