CAJ | 학술논문

目的探讨乳腺浸润性导管癌(IDC)X线表现、病理与分子生物学标记之间的关系.方法分析93例经乳腺X线检查、手术及病理证实的IDC患者的X线表现,术后标本应用免疫组化染色测定癌细胞雌激素受体(ER)、孕激素受体(PR)、癌基因(C-erbB-2)的表达情况,并分析与X线表现之间的关系.结果 93例IDC中,癌肿毛刺状边缘与癌细胞ER阳性表达之间呈正相关(P<0.05);癌肿钙化与C-erbB-2阳性表达之问呈正相关(P<0.05),而与癌细胞ER和PR阳性表达水平之间呈负相关(P>0.05);淋巴结转移与癌细胞ER和PR阳性表达之间呈正相关(P<0.05),C-erbB-2阳性表达率与有无淋巴结转移及病理组织学分级有关(P<0.05).结论 IDC的X线表现、病理与癌细胞ER、PR、C-erbB-2异常表达有一定的相关性,X线表现可以粗略推测ER、PR及C-erbB-2表达情况,对预测IDC淋巴结转移及判断预后有重要意义.
목적 탐토유선침윤성도관암(IDC)X선표현、병리여분자생물학표기지간적관계.방법 분석93례경유선X선검사、수술급병리증실적IDC환자적X선표현,술후표본응용면역조화염색측정암세포자격소수체(ER)、잉격소수체(PR)、암기인(C-erbB-2)적표체정황,병분석여X선표현지간적관계.결과 93례IDC중,암종모자상변연여암세포ER양성표체지간정정상관(P<0.05);암종개화여C-erbB-2양성표체지문정정상관(P<0.05),이여암세포ER화PR양성표체수평지간정부상관(P>0.05);림파결전이여암세포ER화PR양성표체지간정정상관(P<0.05),C-erbB-2양성표체솔여유무림파결전이급병리조직학분급유관(P<0.05).결론 IDC적X선표현、병리여암세포ER、PR、C-erbB-2이상표체유일정적상관성,X선표현가이조략추측ER、PR급C-erbB-2표체정황,대예측IDC림파결전이급판단예후유중요의의.
Objective To investigate the correlation among mammographic features、pathology and molecu-lar biology markers of breast infitrating ductal carcinoma(IDC) tissues.Methods The mammographic features of 93 cases with IDC confirmed by surgery and histopathology were analyzed retrospectively.The mastectomy specimens of the IDC were stained with immunohistochemistry,and the expression of ER、PR、C-erbB-2 were measured.The rela-tionship between the immunohistochemical pathologic results and mammographic features was analyzed.Results A-mong the 93 cases of IDC,ER positive expression was positively correlated with the spiculate margin of breast cancer (P<0.05);C-erbB-2 positive expression was positively correlated(P<0.05).Moreover,ER and PR positive expres-sion showed a significant inverse correlation with the calcifying of breast cancer(P>0.05);ER and PR positive ex-pression was positively correlated with the transfer of lymph(P<0.05);there existed correlation between the positive expression of C-erbB-2 and lymphatic metastasis and pathohistology grade(P<0.05).Conclusion There was a pos-itive correlation among IDC mammography、pathology and the abnormal value of ER、PR and C-erbB-2.The X-ray mammography could reflect the diagnosis value of ER、PR and C-erbB-2 roughly,and thadpractical value in determi-ning prognoses and endocrinotherapy.