CAJ | 학술논문

目的探讨酒精依赖者静息状态下脑功能活动特点.方法选取酒精依赖者24例(酒精依赖组),以及22名与酒精依赖组在年龄、性别、受教育程度以及左、右利手等相匹配的健康志愿者(健康对照组),采用梯度回波-平面回波成像(GRE-EPI)序列行3.0TMR扫描,获取全脑静息态数据,选用DPARSF软件进行数据处理,计算2组受试者的全脑比率低频振荡振幅(fALFF)值.采用REST软件对2组fALFF数据行双样本t检验.最终获取fALFF值有统计学意义的脑区功能图像.结果酒精依赖组较正常对照组fALFF值降低的脑区为双侧额叶内侧回、右枕下侧回、左侧楔前叶、左侧颞下回及左侧小脑后叶(酒精依赖组fALFF值为0.64 ～ 1.69,正常对照组为0.87 ～ 1.78,t值为-4.23 ～ -2.79,P值均＜0.05)；酒精依赖组较正常对照组fALFF升高的脑区为前扣带回、双侧额下回、右侧额中回、双侧岛叶及双侧丘脑(酒精依赖组fALFF值为0.86 ～1.82,正常对照组为0.76～1.58,t值为3.56 ～3.96,P值均＜0.05).结论酒精依赖者双侧前额叶、前扣带回、双侧丘脑、双侧岛叶、左侧小脑等脑区静息态功能活动异常；这些功能区的异常可能与酒精依赖者临床表现及脑部病理生理改变有关.
목적 탐토주정의뢰자정식상태하뇌공능활동특점.방법 선취주정의뢰자24례(주정의뢰조),이급22명여주정의뢰조재년령、성별、수교육정도이급좌、우리수등상필배적건강지원자(건강대조조),채용제도회파-평면회파성상(GRE-EPI)서렬행3.0TMR소묘,획취전뇌정식태수거,선용DPARSF연건진행수거처리,계산2조수시자적전뇌비솔저빈진탕진폭(fALFF)치.채용REST연건대2조fALFF수거행쌍양본t검험.최종획취fALFF치유통계학의의적뇌구공능도상.결과 주정의뢰조교정상대조조fALFF치강저적뇌구위쌍측액협내측회、우침하측회、좌측설전협、좌측섭하회급좌측소뇌후협(주정의뢰조fALFF치위0.64 ～ 1.69,정상대조조위0.87 ～ 1.78,t치위-4.23 ～ -2.79,P치균＜0.05)；주정의뢰조교정상대조조fALFF승고적뇌구위전구대회、쌍측액하회、우측액중회、쌍측도협급쌍측구뇌(주정의뢰조fALFF치위0.86 ～1.82,정상대조조위0.76～1.58,t치위3.56 ～3.96,P치균＜0.05).결론 주정의뢰자쌍측전액협、전구대회、쌍측구뇌、쌍측도협、좌측소뇌등뇌구정식태공능활동이상；저사공능구적이상가능여주정의뢰자림상표현급뇌부병리생리개변유관.
Objective To explore brain activity features during the resting state in alcohol dependent individuals,and study the relationship between the brain activity features and alcohol dependent individuals' clinical symptoms.Methods Twenty-four alcohol dependent individuals and 22 healthy control subjects,well matched in gender,age,education and handedness,were enrolled as the alcohol dependent group and control group respectively.AGE 3.0 T MR scanner was used to acquire all the subjects' resting state data. DPARSF software was used to process resting functional MRI data,and then the whole brain fractional amplitudes of low frequency fluctuation (fALFF) data were acquired.Two-sample t test statistical analysis was made to access fALFF difference between the two groups. Results In comparison with the control group,the alcohol dependent group showed reduced fALFF in bilateral medial prefrontal gyrus,right inferior occipital gyrus,left precuneus,left inferior temporal gyrus,and left posterior lobe of cerebellum (0.64-1.69 vs.0.87-1.78,t =- 4.23- - 2.79,P ＜ 0.05 ). fALFF was increased in the alcohol dependent group at the anterior cingulate,bilateral inferior frontal gyrus,right middle frontal gyrus,bilateral insular lobe,bilateral dorsal thalamus ( 0.86-1.82 vs. 0.76-1.58,t =3.56-3.96,P ＜ 0.05 ).Conclusion Alcohol dependent individuals had abnormal activity at the bilateral prefrontal lobe,anterior cingulate,bilateral dorsal thalamus,bilateral insular lobe,left posterior lobe of cerebellum et al,during the resting state,and these abnormal activities might be related with clinical manifestation and pathophysiology.