CAJ | 학술논문

目的探讨大肠癌淋巴管形成的临床病理意义.方法应用新型特异淋巴管标记物D2-40检测96例大肠癌中心区、周边区及相应正常组织中的淋巴管密度(LVD),并结合临床病理参数进行分析.结果大肠癌中心区LVD(14.5±2.4)个/高倍镜明显高于周边区(6.7±1.2)个/高倍镜及正常组织(5.9±1.1)个/高倍镜(P均<0.01),周边区LVD高于正常组织(P<0.01).周边区LVD与浸润深度和肝转移密切相关(r=0.71,0.78,P均<0.05),而与肿瘤大小、大体类型及淋巴结转移无关(P均>0.05).中心区LVD与肿瘤大小、大体类型、浸润深度、淋巴结转移及肝转移无关(P均>0.05).结论大肠癌周边区淋巴管形成是判断其肝转移和不良预后的依据.
목적 탐토대장암림파관형성적림상병리의의.방법 응용신형특이림파관표기물D2-40검측96례대장암중심구、주변구급상응정상조직중적림파관밀도(LVD),병결합림상병리삼수진행분석.결과 대장암중심구LVD(14.5±2.4)개/고배경명현고우주변구(6.7±1.2)개/고배경급정상조직(5.9±1.1)개/고배경(P균<0.01),주변구LVD고우정상조직(P<0.01).주변구LVD여침윤심도화간전이밀절상관(r=0.71,0.78,P균<0.05),이여종류대소、대체류형급림파결전이무관(P균>0.05).중심구LVD여종류대소、대체류형、침윤심도、림파결전이급간전이무관(P균>0.05).결론대장암주변구림파관형성시판단기간전이화불량예후적의거.
Objective To investigate the clinical pathologic significance of lymphangiogenesis in in colorectal cancer. Methods New lymphatic-specific markers D2-40 was used immunohistochemically to detect the lymphatic vessel density(LVD) in the intratumoural and peritumoral areas, and in normal tissue from 96 cases of colorectal cancer, which were analyzed with clinical pathologic parameters of those colorectal cancer. Results Significandy higher LVD was found in the intratumoural area(14.5±2.4), when compared with normal(5.9±1.1)and peritumoural areas(6.7±1.2) (P<0.01). LVD of the peritumoural area was higher than normal area (P< 0.01). However, peritumoural LVD was associated with both depth of invasion and liver metastasis (r=0.71,0.78 P<0.05), but not associated with tumour size, macroscopic type and lymph-node metastasis (P>0.05). Intratu-moural LVD was not correlated with tumour size, macroscopic type, the depth of invasion,lymph-node metastasis, and liver metastasis(P>0.05). Conclusion Lymphangiogenesis in the peritumoural area may be helpful in evalution of liver metastasis and prognosis.