中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2011年
10期
1037-1042
,共6页
阳赣萍%彭司华%左双燕%王一任%彭小宁%曾小敏
暘贛萍%彭司華%左雙燕%王一任%彭小寧%曾小敏
양공평%팽사화%좌쌍연%왕일임%팽소저%증소민
瘦素受体%LEPR Gln223Arg%LEPR Prol019Pro%基因多态性%肥胖%Meta分析
瘦素受體%LEPR Gln223Arg%LEPR Prol019Pro%基因多態性%肥胖%Meta分析
수소수체%LEPR Gln223Arg%LEPR Prol019Pro%기인다태성%비반%Meta분석
Leptin receptor%LEPR Gln223Arg%LEPR Prol019Pro%Gene polymorphism%Obesity%Meta-analysis
目的 探讨瘦素受体(LEPR) Gln223Arg、Prol019Pro基因多态性与肥胖的关联性.方法 计算机检索万方、CNKI、维普、CBM、PubMed、EMBASE数据库,收集1979-2010年公开发表的关于中国人群LEPR Gln223Arg、LEPR Pro1 019Pro基因多态性与肥胖的病例对照研究的文献,选择OR值及其95％CI作为Meta分析指标.利用Stata 10.0软件对各研究结果进行异质性检验和效应值合并计算.结果 根据统一的纳入和剔除标准,纳入15篇文献,其中LEPRGln223Arg基因多态性相关文献9篇,共有肥胖者1096例,对照组949人;LEPR Prol019Pro基因多态性相关文献8篇,共有肥胖者961例,对照组818人.LEPR Gln223Arg基因多态性与肥胖关联性的研究中,LEPR-668位点基因G/A的OR=0.66(95％CI:0.49～0.89),将有A→3基因突变的AG基因型和GG基因型合并后与AA基因型比较,肥胖易感性降低(OR=0.50,95％CI:0.32～0.77)有统计学意义;在LEPR Prol019Pro基因多态性与肥胖关联性的研究中,LEPR-3057位点基因A/G的OR=1,61 (95％CI:1.15～2.26),有G→A基因突变的基因型AG和基因型AA合并后与GG基因型比较,肥胖易感性升高(OR=1.50,95％CI:1.08～2.08),有统计学意义.结论 中国汉族为主的人群LEPR Gln223Arg和LEPR Prol019Pro基因多态性与肥胖的发生均有关联.
目的 探討瘦素受體(LEPR) Gln223Arg、Prol019Pro基因多態性與肥胖的關聯性.方法 計算機檢索萬方、CNKI、維普、CBM、PubMed、EMBASE數據庫,收集1979-2010年公開髮錶的關于中國人群LEPR Gln223Arg、LEPR Pro1 019Pro基因多態性與肥胖的病例對照研究的文獻,選擇OR值及其95％CI作為Meta分析指標.利用Stata 10.0軟件對各研究結果進行異質性檢驗和效應值閤併計算.結果 根據統一的納入和剔除標準,納入15篇文獻,其中LEPRGln223Arg基因多態性相關文獻9篇,共有肥胖者1096例,對照組949人;LEPR Prol019Pro基因多態性相關文獻8篇,共有肥胖者961例,對照組818人.LEPR Gln223Arg基因多態性與肥胖關聯性的研究中,LEPR-668位點基因G/A的OR=0.66(95％CI:0.49～0.89),將有A→3基因突變的AG基因型和GG基因型閤併後與AA基因型比較,肥胖易感性降低(OR=0.50,95％CI:0.32～0.77)有統計學意義;在LEPR Prol019Pro基因多態性與肥胖關聯性的研究中,LEPR-3057位點基因A/G的OR=1,61 (95％CI:1.15～2.26),有G→A基因突變的基因型AG和基因型AA閤併後與GG基因型比較,肥胖易感性升高(OR=1.50,95％CI:1.08～2.08),有統計學意義.結論 中國漢族為主的人群LEPR Gln223Arg和LEPR Prol019Pro基因多態性與肥胖的髮生均有關聯.
목적 탐토수소수체(LEPR) Gln223Arg、Prol019Pro기인다태성여비반적관련성.방법 계산궤검색만방、CNKI、유보、CBM、PubMed、EMBASE수거고,수집1979-2010년공개발표적관우중국인군LEPR Gln223Arg、LEPR Pro1 019Pro기인다태성여비반적병례대조연구적문헌,선택OR치급기95％CI작위Meta분석지표.이용Stata 10.0연건대각연구결과진행이질성검험화효응치합병계산.결과 근거통일적납입화척제표준,납입15편문헌,기중LEPRGln223Arg기인다태성상관문헌9편,공유비반자1096례,대조조949인;LEPR Prol019Pro기인다태성상관문헌8편,공유비반자961례,대조조818인.LEPR Gln223Arg기인다태성여비반관련성적연구중,LEPR-668위점기인G/A적OR=0.66(95％CI:0.49～0.89),장유A→3기인돌변적AG기인형화GG기인형합병후여AA기인형비교,비반역감성강저(OR=0.50,95％CI:0.32～0.77)유통계학의의;재LEPR Prol019Pro기인다태성여비반관련성적연구중,LEPR-3057위점기인A/G적OR=1,61 (95％CI:1.15～2.26),유G→A기인돌변적기인형AG화기인형AA합병후여GG기인형비교,비반역감성승고(OR=1.50,95％CI:1.08～2.08),유통계학의의.결론 중국한족위주적인군LEPR Gln223Arg화LEPR Prol019Pro기인다태성여비반적발생균유관련.
Objective To evaluate the associations between polymorphisms of LEPR Gln223Arg,LEPR Pro 1019Pro and the risk on obesity.Methods A computerized search on literature was carried out in Wanfang,CNKI,VIP databases and CBM,PubMed,EMBASE databases to collect articles published between 1979 and 2010 concerning the associations between polymorphisms of LEPR Gln223Arg and/or LEPR Pro 1019Pro and risk of obesity in the Chinese population.Odds ratios (ORs) were used to assess the strength of the association,and 95％ confidence intervals (CIs) to present the precision of the estimates.Meta-analysis was performed using the STATA statistical software.Results Fifteen literature were collected for Meta-analysis by the uniform inclusion and exclusion criteria.There were 1096 obese patients and 949 controls for polymorphisms of LEPR Gln223Arg in 9 papers,together with 961 obese patients and 818 controls for polymorphisms of LEPR Prol019Pro in 8 papers.Overall,there were significant associations between decreased risk of obesity and LEPR Gln223Arg polymorphisms (-668 A→G) (G versus A,OR=0.66,95％CI:0.49-0.89; AG and GG versus AA,OR=0.50,95％CI:0.32-0.77; respectively).There were significant associations between increased risk of obesity and LEPR Prol019Pro polymorphisms (-3057 G→A) (A versus G,OR=1.61,95％CI:1.15-2.26; AG and AA versus GG,OR=1.50,95％CI:1.08-2.08; respectively).Conclusion Variant alleles at both LEPR-668 and LEPR-3057 were associated with obesity in the Chinese Han-dominated population.
