中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2010年
3期
165-167
,共3页
季芳%刘承延%石华英%祁小娟
季芳%劉承延%石華英%祁小娟
계방%류승연%석화영%기소연
多发腔隙性脑梗死%轻度认知功能障碍%痴呆
多髮腔隙性腦梗死%輕度認知功能障礙%癡呆
다발강극성뇌경사%경도인지공능장애%치태
Lacunar%Mild cognitive%Impairment%Dementia
目的 探讨多发性腔隙性脑梗死(multiple lacunar infarction,MLI)对轻度认知功能损害(mild cognitive impairment,MCI)患者发展为痴呆的相关关系.方法 采用国际通用标准从门诊和住院患者中筛选轻度认知功能障碍患者.通过MRI和CT扫描,确定这些患者有否多发性腔隙性脑梗死.对轻度认知功能障碍患者进行随访,用Kapaln-Meier生存分析法评定MLI对MCI发展为痴呆的相关关系.结果 经临床和神经心理学评估,有120例MCI患者入选,其中43例(35.8%)经影像学诊断为伴有MLI,77例(64.1%)不伴MLI.经6～24个月随访,伴有MLI的患者有27(62.8%)例进展为痴呆,不伴MLI的患者有15例(19.4%)进展为痴呆.随访期内伴有MLI的MCI患者进展为痴呆的比例显著高于不伴MLI的患者(P＜0.05).结论 伴有MLI的MCI患者更容易进展为痴呆.这类MCI患者必须尽早进行干预,去除可控危险因素,预防痴呆发生.
目的 探討多髮性腔隙性腦梗死(multiple lacunar infarction,MLI)對輕度認知功能損害(mild cognitive impairment,MCI)患者髮展為癡呆的相關關繫.方法 採用國際通用標準從門診和住院患者中篩選輕度認知功能障礙患者.通過MRI和CT掃描,確定這些患者有否多髮性腔隙性腦梗死.對輕度認知功能障礙患者進行隨訪,用Kapaln-Meier生存分析法評定MLI對MCI髮展為癡呆的相關關繫.結果 經臨床和神經心理學評估,有120例MCI患者入選,其中43例(35.8%)經影像學診斷為伴有MLI,77例(64.1%)不伴MLI.經6～24箇月隨訪,伴有MLI的患者有27(62.8%)例進展為癡呆,不伴MLI的患者有15例(19.4%)進展為癡呆.隨訪期內伴有MLI的MCI患者進展為癡呆的比例顯著高于不伴MLI的患者(P＜0.05).結論 伴有MLI的MCI患者更容易進展為癡呆.這類MCI患者必鬚儘早進行榦預,去除可控危險因素,預防癡呆髮生.
목적 탐토다발성강극성뇌경사(multiple lacunar infarction,MLI)대경도인지공능손해(mild cognitive impairment,MCI)환자발전위치태적상관관계.방법 채용국제통용표준종문진화주원환자중사선경도인지공능장애환자.통과MRI화CT소묘,학정저사환자유부다발성강극성뇌경사.대경도인지공능장애환자진행수방,용Kapaln-Meier생존분석법평정MLI대MCI발전위치태적상관관계.결과 경림상화신경심이학평고,유120례MCI환자입선,기중43례(35.8%)경영상학진단위반유MLI,77례(64.1%)불반MLI.경6～24개월수방,반유MLI적환자유27(62.8%)례진전위치태,불반MLI적환자유15례(19.4%)진전위치태.수방기내반유MLI적MCI환자진전위치태적비례현저고우불반MLI적환자(P＜0.05).결론 반유MLI적MCI환자경용역진전위치태.저류MCI환자필수진조진행간예,거제가공위험인소,예방치태발생.
Objective To evaluate the impact of multiple lacunar infarction (MLI) on the outcomes of mild cognitive impairment (MCI). Methods MCI patients were selected in outpatients and hospitalized patients using a common international standard MCI screen. Magnetic resonance imaging (MRI) and computer tomography (CT) were used to determine the presence of MLI. MCI patients were followed up for 6～24 months and their cognitive status and the impact of MLI on MCI were evaluated using Kaplan-Meier survival analysis. Results One hundred twenty patients were diagnosed as having MCI based on clinical evaluation and neuropsychological assessment. Among them, 43 (35.8%) patients had MLI and the rest 77 (64.1%) patients did not have. Twenty-seven MCI patients with MLI (62.8%) developed dementia, while 15 MCI patients without MLI (19.4%) developed dementia during 6～24 months follow-up. Kaplan-Meier analysis indicated that the incidence of dementia was significantly higher in patients with MLI than in patients without MLI did (P＜0.05). Conclusions MCI patients with MLI are more prone to dementia. These results suggest that early interventions aimed at controlling the modifiable risks are warranted for dementia prevention in MCI patients with MLI.
