CAJ | 학술논문

背景:脑源性生长因子具有促进神经元生长存活,引导轴突延伸塑型的作用.周围神经损伤后的再生和髓鞘形成需要内源性脑源性神经生长因子.目的:归纳总结脑源性生长因子的研究现状.方法:以中文检索词"神经再生;脑源性生长因子"和英文检索词"nerve,regeneration,BDNF"检索2000-01/2009-08中国期刊全文数据库和Pubmed数据库.纳入具有原创性、论点论据可靠的试验文章,观点明确,分析全面的文章,及文献主题与此课题关系紧密的文章.排除重复性研究和综述文章.结果与结论:神经损伤后在髓鞘形成过程中脑源性神经生长因子通过高亲和力Trk受体和低亲和力受体P75~(NTR)促进髓鞘形成.与神经生长因子在周围靶组织合成不同,脑源性神经生长因子主要在中枢神经系统中合成,但当周围神经受损后其mRNA表达增多,大量的实验表明正常周围神经的许旺细胞同样有少量脑源性神经生长因子表达.现在人们通过将脑源性神经生长因子基因通过病毒介导转染干细胞后移植到神经损伤区域治疗疾病,有望成为新的治疗方法.
배경:뇌원성생장인자구유촉진신경원생장존활,인도축돌연신소형적작용.주위신경손상후적재생화수초형성수요내원성뇌원성신경생장인자.목적:귀납총결뇌원성생장인자적연구현상.방법:이중문검색사"신경재생;뇌원성생장인자"화영문검색사"nerve,regeneration,BDNF"검색2000-01/2009-08중국기간전문수거고화Pubmed수거고.납입구유원창성、론점론거가고적시험문장,관점명학,분석전면적문장,급문헌주제여차과제관계긴밀적문장.배제중복성연구화종술문장.결과여결론:신경손상후재수초형성과정중뇌원성신경생장인자통과고친화력Trk수체화저친화력수체P75~(NTR)촉진수초형성.여신경생장인자재주위파조직합성불동,뇌원성신경생장인자주요재중추신경계통중합성,단당주위신경수손후기mRNA표체증다,대량적실험표명정상주위신경적허왕세포동양유소량뇌원성신경생장인자표체.현재인문통과장뇌원성신경생장인자기인통과병독개도전염간세포후이식도신경손상구역치료질병,유망성위신적치료방법.
BACKGROUND:Brain-derived neurotrophic factor (BDNF) can promote neuron development and survival, and axon prolongation and modeling. Peripheral nerve regeneration and myelin formation after injury need endogenous BDNF. OBJECTIVE: To summarize research status of BDNF. METHODS: A computer-based online search of CNKl and Pubmed databases was performed for articles published between January 2000 and August 2009 with the key words "nerve regeneration, BDNF" in Chinese and English. Articles with creativity, reliable evidence and close correlation with the content were included. Repetitive and review articles were excluded. RESULTS AND CONCLUSION: BDNF boosts myelin formation by binding to high-affinity receptor Trk and low-affinity receptor p75NTR.Compared to nerve growth factor (NGF) synthesized in surrouding target tissues, BDNF is mainly synthesized in central nervous system. However, BDNF mRNA is expressed increasingly following peripheral nerve injury. Various of experiments have demonstrated that normal peripheral Schwann cells can express a little BDNF. Currently, BDNF gene has been mediated through virus, transfected into stem cells, which can be transplanted into injured nerve sites.