CAJ | 학술논문

目的建立载瘤动脉类似于人体颈内动脉虹吸段形态的犬动脉瘤模型.方法用3.0 T MR行3维(3D)-时间飞跃(TOF)-MR血管成像(MRA)序列采集人头颅横断面医学数字图像通讯(DICOM)格式图像,导人Materialise Mimics和Pro-E软件重组,做出带孔管状3D数字模型.根据该文件利用快速原型技术制作出 TangoPlus材料的实体模型并硅胶涂层.分别将6只实验犬左侧颈总动脉远端和右侧颈总动脉近端结扎离断.将游离的左侧颈总动脉通过黑线牵引从下而上,游离的右侧颈总动脉从右剑左穿过模型,并从模型上的孔牵出.处理游离的双侧颈总动脉外膜后,行端侧吻合,得到形态类似于人颈内动脉虹吸段动脉瘤形态的动脉瘤模型.动物模型完成后即刻及1周MRA随访,1周行血管造影并置入测试支架测试.结果 6只犬均成功建立了形态类似于人颈内动脉虹吸段动脉瘤的动脉瘤模型.MRA显示6只犬的载瘤动脉通畅,显影良好.置人支架后1只犬死亡;5只术后1个月随访,模型内血管均通畅,其中3只弯曲处血管变扁,2 只无明显管腔形态改变.结论制作的模型弯曲血管与人体颈内动脉虹吸段形态高度相似,可作为颅内神经介入材料及其输送系统的研究测试以及神经介入医师培训的工具.
목적 건립재류동맥유사우인체경내동맥홍흡단형태적견동맥류모형.방법 용3.0 T MR행3유(3D)-시간비약(TOF)-MR혈관성상(MRA)서렬채집인두로횡단면의학수자도상통신(DICOM)격식도상,도인Materialise Mimics화Pro-E연건중조,주출대공관상3D수자모형.근거해문건이용쾌속원형기술제작출 TangoPlus재료적실체모형병규효도층.분별장6지실험견좌측경총동맥원단화우측경총동맥근단결찰리단.장유리적좌측경총동맥통과흑선견인종하이상,유리적우측경총동맥종우검좌천과모형,병종모형상적공견출.처리유리적쌍측경총동맥외막후,행단측문합,득도형태유사우인경내동맥홍흡단동맥류형태적동맥류모형.동물모형완성후즉각급1주MRA수방,1주행혈관조영병치입측시지가측시.결과 6지견균성공건립료형태유사우인경내동맥홍흡단동맥류적동맥류모형.MRA현시6지견적재류동맥통창,현영량호.치인지가후1지견사망;5지술후1개월수방,모형내혈관균통창,기중3지만곡처혈관변편,2 지무명현관강형태개변.결론 제작적모형만곡혈관여인체경내동맥홍흡단형태고도상사,가작위로내신경개입재료급기수송계통적연구측시이급신경개입의사배훈적공구.
Objective The aim of the experiment is to make an intracranial aneurysm model in canine.Methods A digital tube was made based on raw magnetic resonance images of the human intracraaial carotid artery.Then 6 tubes were made in the 3 D rapid prototyping machine and coated with silicone.Finally we isolated the common carotid arteries of 6 canines and made them go through the tubes and anastomosed them end-to-side to get the aneurysm model.Six stents were implanted after one week.Results Six aneurysm models were successfully made in canines.The parent artery had similar geometrv of the human carotid siphon.All the aneurysms and parent arteries were patent in one week's follow-up.One canine died of excessive anesthesia after stentingr Two vaseular models kept patent in one month without stenosis.The other 3 had some stenosis on the bends of the vessel.Conclusions The aneurysm model in tIle experiment has high flexibility and reliability.The model provides an effective tool for research and testing neurovascular devices.It's also a useful device to train the neuroradiologists and interventional physicians.