CAJ | 학술논문

目的观察非酒精性脂肪性肝病(NAFLD)患者的不同肥胖程度与胰岛素抵抗(IR)状态的相关性.方法对符合诊断的168例NAFLD患者测定身高、体质量、空腹血糖(FPG)、及空腹胰岛素(FINS),计算体质量指数(BMI)和稳态模型IR指数(HOMA-IRI),以同期不嗜酒的32例健康人作为对照.结果与健康对照组比较,NAFLD患者BMI、FPG、FINS、HOMA-IRI水平明显升高,差异均有统计学意义(P均＜0.05).而NAFLD患者中,随着肥胖程度的增加,IR也随之逐渐加重,差异具有统计学意义(P均＜0.05).结论 NAFLD患者存在着明显的高胰岛素血症和IR,肥胖可加重了患者的IR,并继发糖代谢紊乱.
목적 관찰비주정성지방성간병(NAFLD)환자적불동비반정도여이도소저항(IR)상태적상관성.방법 대부합진단적168례NAFLD환자측정신고、체질량、공복혈당(FPG)、급공복이도소(FINS),계산체질량지수(BMI)화은태모형IR지수(HOMA-IRI),이동기불기주적32례건강인작위대조.결과 여건강대조조비교,NAFLD환자BMI、FPG、FINS、HOMA-IRI수평명현승고,차이균유통계학의의(P균＜0.05).이NAFLD환자중,수착비반정도적증가,IR야수지축점가중,차이구유통계학의의(P균＜0.05).결론 NAFLD환자존재착명현적고이도소혈증화IR,비반가가중료환자적IR,병계발당대사문란.
Objective To investigate the correlation between degree of obesity and insulin resistance （IR) in patients with nonalcoholic fatty liver disease (NAFLD). Methods A total of 168 patients with NAFLD were enrolled and 32 healthy subjects were served as controls spontaneously.Body height,weight,fasting blood-glucose (FPG) and fasting insulin (FINS) were recorded and body mass index (BMI) and homeostasis model assessment of insulin resistance index (HOMAIRI) were calculated. Results Levels of BMI,FPG,FINS,HOMA-IRI in patients with NAFLD were all elevated as compared with the controls (all P ＜ 0.05). Meanwhile, with the progressive development of obesity,the IR was gradually enhanced (all P ＜ 0.05). Conclusions Hyperinsulinemia and IR may occurred in patients with NAFLD. Moreover,Obesity can aggravate IR and induce secondary glycometabolic disorder.