国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2011年
1期
21-23
,共3页
轮状病毒感染%NF-κB
輪狀病毒感染%NF-κB
륜상병독감염%NF-κB
Rotavirus infection%NF-κB
轮状病毒感染后,NF-κB在宿主防御反应及轮状病毒致病性中均起着重要的调控作用.一方面,宿主通过NF-κB介导的信号调控机制发挥抗病毒及相关免疫作用;另一方面,轮状病毒可通过阻断NF-κB细胞核聚集等反应逃避宿主的免疫反应.因此,轮状病毒感染后的结局可能取决于占优势的NF-κB调控方式.
輪狀病毒感染後,NF-κB在宿主防禦反應及輪狀病毒緻病性中均起著重要的調控作用.一方麵,宿主通過NF-κB介導的信號調控機製髮揮抗病毒及相關免疫作用;另一方麵,輪狀病毒可通過阻斷NF-κB細胞覈聚集等反應逃避宿主的免疫反應.因此,輪狀病毒感染後的結跼可能取決于佔優勢的NF-κB調控方式.
륜상병독감염후,NF-κB재숙주방어반응급륜상병독치병성중균기착중요적조공작용.일방면,숙주통과NF-κB개도적신호조공궤제발휘항병독급상관면역작용;령일방면,륜상병독가통과조단NF-κB세포핵취집등반응도피숙주적면역반응.인차,륜상병독감염후적결국가능취결우점우세적NF-κB조공방식.
In rotavirus infection, NF-κB plays an important role in regulation of host defense and pathogenic of rotavirus. On the one hand, by the signal regulation mechanism of NF-κ Bmediated, host plays antiviral effect and immune-related role. On the other hand, by blocking NF-κB nuclear accumulation and other reactions, rotavirus evades the host immune response. Consequently, the outcome of rotavirus infection may depend on dominant way of NF-κ Bregulating.
