国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2012年
4期
239-242
,共4页
邓敏%宣华%张戡%谢新生
鄧敏%宣華%張戡%謝新生
산민%선화%장감%사신생
肝炎病毒,乙型%肝活检%白蛋白%球蛋白%HBV DNA
肝炎病毒,乙型%肝活檢%白蛋白%毬蛋白%HBV DNA
간염병독,을형%간활검%백단백%구단백%HBV DNA
Hepatitis B virus%Liver biopsy%Albumin%Globulin%HBV DNA
目的 分析慢性HBV携带者血清白蛋白(ALB)、球蛋白(GLB)、HBV DNA定量与肝组织炎症分级、纤维化分期的关系,探讨肝活检的重要性及价值.方法 对76例慢性HBV携带者的血清ALB、GLB、HBV DNA定量与肝穿病理分级、分期的关系进行分析；统计慢性HBV携带者临床诊断与病理诊断的符合情况.结果 76例慢性HBV携带者中,65例(85.53％)患者均存在不同程度的炎症(G)及纤维化(S)改变,其中G146例,占60.53％,G2-430例,占39.47％；S0-156例,占73.68％,S2-4 20例,占26.32％.ALB水平G0-1明显高于G2-4(t=7.954,P＜0.01),s1明显高于S2-4(t=9.405,P＜0.01)；而GLB水平则相反(t=6.669,P＜0.01;t＝2.508,P＜0.05).HBV DNA不同复制水平与肝组织炎症及纤维化不同分级组间比较差异均无统计学意义(x2=0.034、0.819,P＞0.05).≥40岁年龄组纤维化程度较重,与＜40岁组比较差异有统计学意义( x2=6.220,P＜0.05).结论 动态监测慢性HBV携带者血清ALB、GLB在一定程度上有助于判断疾病的程度,但要确诊肝组织炎症分级及纤维化分期,肝组织病理活检是必需的.
目的 分析慢性HBV攜帶者血清白蛋白(ALB)、毬蛋白(GLB)、HBV DNA定量與肝組織炎癥分級、纖維化分期的關繫,探討肝活檢的重要性及價值.方法 對76例慢性HBV攜帶者的血清ALB、GLB、HBV DNA定量與肝穿病理分級、分期的關繫進行分析；統計慢性HBV攜帶者臨床診斷與病理診斷的符閤情況.結果 76例慢性HBV攜帶者中,65例(85.53％)患者均存在不同程度的炎癥(G)及纖維化(S)改變,其中G146例,佔60.53％,G2-430例,佔39.47％；S0-156例,佔73.68％,S2-4 20例,佔26.32％.ALB水平G0-1明顯高于G2-4(t=7.954,P＜0.01),s1明顯高于S2-4(t=9.405,P＜0.01)；而GLB水平則相反(t=6.669,P＜0.01;t＝2.508,P＜0.05).HBV DNA不同複製水平與肝組織炎癥及纖維化不同分級組間比較差異均無統計學意義(x2=0.034、0.819,P＞0.05).≥40歲年齡組纖維化程度較重,與＜40歲組比較差異有統計學意義( x2=6.220,P＜0.05).結論 動態鑑測慢性HBV攜帶者血清ALB、GLB在一定程度上有助于判斷疾病的程度,但要確診肝組織炎癥分級及纖維化分期,肝組織病理活檢是必需的.
목적 분석만성HBV휴대자혈청백단백(ALB)、구단백(GLB)、HBV DNA정량여간조직염증분급、섬유화분기적관계,탐토간활검적중요성급개치.방법 대76례만성HBV휴대자적혈청ALB、GLB、HBV DNA정량여간천병리분급、분기적관계진행분석；통계만성HBV휴대자림상진단여병리진단적부합정황.결과 76례만성HBV휴대자중,65례(85.53％)환자균존재불동정도적염증(G)급섬유화(S)개변,기중G146례,점60.53％,G2-430례,점39.47％；S0-156례,점73.68％,S2-4 20례,점26.32％.ALB수평G0-1명현고우G2-4(t=7.954,P＜0.01),s1명현고우S2-4(t=9.405,P＜0.01)；이GLB수평칙상반(t=6.669,P＜0.01;t＝2.508,P＜0.05).HBV DNA불동복제수평여간조직염증급섬유화불동분급조간비교차이균무통계학의의(x2=0.034、0.819,P＞0.05).≥40세년령조섬유화정도교중,여＜40세조비교차이유통계학의의( x2=6.220,P＜0.05).결론 동태감측만성HBV휴대자혈청ALB、GLB재일정정도상유조우판단질병적정도,단요학진간조직염증분급급섬유화분기,간조직병리활검시필수적.
Objective To analyze correlation between hepatic:damage or fibrosis and albumin(AIB),globulin (GLB) and quantity of serum HBV DNA in chronic hepatitis B virus carriers for seeking some better clinical indices.To confirm the difference between clinical diagnosis and pathological diagnosis by means of liver biopsy.Metbods From March 2009 to December 2011,76 liver biopsies of chronic hepatitis B virus carriers were reviewed pathohistologically.albumin( ALB),globulin( CLB) and quantity of HBV DNA were collected sirmultaneously half a month before and after the biopsy. The correlations were assessed between hepatic pathohistology and clinical indices. The coincidence was evaluated between clinical and pathological diagnosis simultaneously.Results About 85.52 ％ ( 65/76 ) of the patients showed different degrees of inflammation(G) or fibrosis(S). For the degree of inflammation C0-1 was 60.53 ％ ( 46/76). and G2-4 was 39.47 ％ ( 30/76). For the degree of fibrosis.S0-1 was 73.68 ％(56/76), and S2-4 was 26.32 ％ ( 20/76). The ALB in patients with inflammation level of C0-1 was much higher than C2-4( t =7.954,P ＜ 0.01 ),and in patients with fibrosis level of S0-1 was higher than S2-4( t =6.669,P ＜ 0.01) ; and the level of GLB were the opposite ( t =2.649.P ＜ 0.01 ; t=2.508,P ＜ 0.05 ). The HBV DNA level was irrelevant with inflammatory staging and fibrotic scoring grading ( x2 =0.034,0.819.P ＞ 0.05). The degree of fibrosis in the age ≥ 40 group was more severe than the age ＜40 group ( x2 =6.220,P ＜ 0.05). Conclusions Serum samples for ALB and CLB are considered tO be the valuable reference for clinical diagnosis.However,liver biopsy is indispensable for confirming liver inflammatory staging and fibrotic scoring grading.
