中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
30期
19-21
,共3页
癌胚抗原%白细胞介素6%白细胞介素8%口腔鳞癌
癌胚抗原%白細胞介素6%白細胞介素8%口腔鱗癌
암배항원%백세포개소6%백세포개소8%구강린암
Carcinoembryonic antigen%Interleukin-6%Interleukin-8%Oral squamous cell carcinoma
目的 探讨口腔鳞癌患者唾液中癌胚抗原(CEA)、白细胞介素(IL)-6、IL-8含量变化及临床意义.方法 选择42例口腔鳞癌患者作为观察组,同时选择同期健康者50例作为对照组.采用ELISA法检测两组血清及唾液中CEA、IL-6、IL-8水平并进行统计学分析.结果 观察组唾液中CEA、IL-6、IL-8水平分别为(62.37±20.80)μgL、(79.12±30.26) ng/L、(834.61±231.85) ng/L,对照组分别为(25.72±12.65) μg/L、(0.58±0.25) ng/L、(209.71±67.92) ng/L,观察组显著高于对照组(P＜0.01)；观察组血清中CEA、IL-6、IL-8水平分别为(61.15±23.69)μg/L、(58.17±12.83) ng/L、(852.31±172.97) ng/L,唾液中IL-6水平显著高于血清(P＜0.05).结论 CEA、IL-6、IL-8可以作为口腔鳞癌患者的生物学标志物,唾液检测简单易行且较血清检测敏感,是口腔鳞癌的理想辅助诊断方法.
目的 探討口腔鱗癌患者唾液中癌胚抗原(CEA)、白細胞介素(IL)-6、IL-8含量變化及臨床意義.方法 選擇42例口腔鱗癌患者作為觀察組,同時選擇同期健康者50例作為對照組.採用ELISA法檢測兩組血清及唾液中CEA、IL-6、IL-8水平併進行統計學分析.結果 觀察組唾液中CEA、IL-6、IL-8水平分彆為(62.37±20.80)μgL、(79.12±30.26) ng/L、(834.61±231.85) ng/L,對照組分彆為(25.72±12.65) μg/L、(0.58±0.25) ng/L、(209.71±67.92) ng/L,觀察組顯著高于對照組(P＜0.01)；觀察組血清中CEA、IL-6、IL-8水平分彆為(61.15±23.69)μg/L、(58.17±12.83) ng/L、(852.31±172.97) ng/L,唾液中IL-6水平顯著高于血清(P＜0.05).結論 CEA、IL-6、IL-8可以作為口腔鱗癌患者的生物學標誌物,唾液檢測簡單易行且較血清檢測敏感,是口腔鱗癌的理想輔助診斷方法.
목적 탐토구강린암환자타액중암배항원(CEA)、백세포개소(IL)-6、IL-8함량변화급림상의의.방법 선택42례구강린암환자작위관찰조,동시선택동기건강자50례작위대조조.채용ELISA법검측량조혈청급타액중CEA、IL-6、IL-8수평병진행통계학분석.결과 관찰조타액중CEA、IL-6、IL-8수평분별위(62.37±20.80)μgL、(79.12±30.26) ng/L、(834.61±231.85) ng/L,대조조분별위(25.72±12.65) μg/L、(0.58±0.25) ng/L、(209.71±67.92) ng/L,관찰조현저고우대조조(P＜0.01)；관찰조혈청중CEA、IL-6、IL-8수평분별위(61.15±23.69)μg/L、(58.17±12.83) ng/L、(852.31±172.97) ng/L,타액중IL-6수평현저고우혈청(P＜0.05).결론 CEA、IL-6、IL-8가이작위구강린암환자적생물학표지물,타액검측간단역행차교혈청검측민감,시구강린암적이상보조진단방법.
Objective To explore salivary concentration of carcinoembryonic antigen (CEA),interleukin (IL)-6,IL-8 in oral squamous cell carcinoma and its' clinical significance.Methods Forty-two cases with oral squamous cell carcinoma were selected as experience group and 50 healthy persons as control group.ELISA method was performed to detect CEA,IL-6,IL-8 level of salivary and serum in two groups.Results The salivary concentration of CEA,IL-6 and IL-8 was (62.37 ± 20.80)μ g/L,(79.12 ± 30.26)ng/L,( 834.61 ± 231.85 ) ng/L respectively in experience group,(25.72 ± 12.65 ) μ g/L,(0.58 ± 0.25 ) ng/L,(209.71 ± 67.92) ng/L in control group.There was significant difference between two groups(P＜ 0.01 ).The serum concentration of CEA,IL-6 and IL-8 was(61.15 ± 23.69)μ g/L,(58.17 ± 12.83) ng/L,(852.31 ±172.97) ng/L respectively in experience group,and IL-6 level of serum were much lower than that of salivary (P ＜ 0.05).Conclusions CEA,IL-6 and IL-8 can be biomarkers of oral squamous cell carcinoma.Salivary detection is an ideal auxiliary diagnosis method for its simplicity and sensitivity.
