中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
9期
1025-1028
,共4页
刘兆董%王雪春%江忠清%戴丽玉%林岷
劉兆董%王雪春%江忠清%戴麗玉%林岷
류조동%왕설춘%강충청%대려옥%림민
宫颈鳞癌%HER3%增殖指数%微血管密度%肿瘤转移%免疫组织化学
宮頸鱗癌%HER3%增殖指數%微血管密度%腫瘤轉移%免疫組織化學
궁경린암%HER3%증식지수%미혈관밀도%종류전이%면역조직화학
Cervical squamous cell carcinoma%HER3%Proliferation index%Microvessel density%Tumor metastasis%Immunohistochemistry
目的 探讨HER3在宫颈鳞状细胞癌组织的表达及其临床意义.方法 采用免疫组化SP法检测HER3在28例宫颈正常上皮(NCE)、36例宫颈上皮内瘤变(CIN)和68例宫颈鳞状细胞癌(SCC)组织的表达,并检测其中Ki-67标记的增殖指数(PI)和CD34标记的微血管密度(MVD).结果 HER3在NCE、CIN及SCC组的阳性表达率分别为10.7%(3/28)、22.2%(8/36)及54.4%(37/68).HER3在SCC组的阳性表达率均高于CIN和NCE组(P＜0.05).HER3在SCC组表达分别与PI及MVD显著正相关(PI:r=0.375,P=0.002;MVD:r=0.273,P=0.024).HER3在SCC组表达分别与FIGO分期及组织学分级有关(P＜0.05),而与患者年龄、有否盆腔淋巴结转移、脉管浸润、间质浸润深度及生存率无关(P＞0.05).FIGO分期为Ⅱ期及组织学分级为Ⅲ级者,其HER3的阳性表达率分别显著高于FIGO分期为Ⅰ期及组织学分级在Ⅱ级以内者(P＜0.05).结论 HER3过度表达可能上调宫颈鳞癌细胞增殖及间质血管新生,可能促进宫颈鳞癌病程进展.
目的 探討HER3在宮頸鱗狀細胞癌組織的錶達及其臨床意義.方法 採用免疫組化SP法檢測HER3在28例宮頸正常上皮(NCE)、36例宮頸上皮內瘤變(CIN)和68例宮頸鱗狀細胞癌(SCC)組織的錶達,併檢測其中Ki-67標記的增殖指數(PI)和CD34標記的微血管密度(MVD).結果 HER3在NCE、CIN及SCC組的暘性錶達率分彆為10.7%(3/28)、22.2%(8/36)及54.4%(37/68).HER3在SCC組的暘性錶達率均高于CIN和NCE組(P＜0.05).HER3在SCC組錶達分彆與PI及MVD顯著正相關(PI:r=0.375,P=0.002;MVD:r=0.273,P=0.024).HER3在SCC組錶達分彆與FIGO分期及組織學分級有關(P＜0.05),而與患者年齡、有否盆腔淋巴結轉移、脈管浸潤、間質浸潤深度及生存率無關(P＞0.05).FIGO分期為Ⅱ期及組織學分級為Ⅲ級者,其HER3的暘性錶達率分彆顯著高于FIGO分期為Ⅰ期及組織學分級在Ⅱ級以內者(P＜0.05).結論 HER3過度錶達可能上調宮頸鱗癌細胞增殖及間質血管新生,可能促進宮頸鱗癌病程進展.
목적 탐토HER3재궁경린상세포암조직적표체급기림상의의.방법 채용면역조화SP법검측HER3재28례궁경정상상피(NCE)、36례궁경상피내류변(CIN)화68례궁경린상세포암(SCC)조직적표체,병검측기중Ki-67표기적증식지수(PI)화CD34표기적미혈관밀도(MVD).결과 HER3재NCE、CIN급SCC조적양성표체솔분별위10.7%(3/28)、22.2%(8/36)급54.4%(37/68).HER3재SCC조적양성표체솔균고우CIN화NCE조(P＜0.05).HER3재SCC조표체분별여PI급MVD현저정상관(PI:r=0.375,P=0.002;MVD:r=0.273,P=0.024).HER3재SCC조표체분별여FIGO분기급조직학분급유관(P＜0.05),이여환자년령、유부분강림파결전이、맥관침윤、간질침윤심도급생존솔무관(P＞0.05).FIGO분기위Ⅱ기급조직학분급위Ⅲ급자,기HER3적양성표체솔분별현저고우FIGO분기위Ⅰ기급조직학분급재Ⅱ급이내자(P＜0.05).결론 HER3과도표체가능상조궁경린암세포증식급간질혈관신생,가능촉진궁경린암병정진전.
Objective To investigate the expressions of HER3 in invasive squamous cell carcinoma of cervix and the clinical significance. Methods The expressions of HER3, Ki-67 and CD34 protein in 28 cases of normal cervical epithelium(NCE), 36 cases of cervical intraepithelial neoplasm(CIN) and 68 cases of squamous cell carcinoma of cervix (SCC) were detected by immunohistochemistry streptavidin-perosidase (SP) method. Results The positive expression rates of HER3 in NCE, CIN and SCC were 10.7%, 22.2% and 54.4%, respectively. The positive expression rates of HER3 increased remarkably from NCE and CIN to SCC (P ＜ 0. 05). The expression of HER3 in SCC was significantly positive correlated with PI and MVD(for PI: r =0.375, P=0. 002; for MVD: r=0.273, P =0. 024). The expression of HER3 in SCC was related with FIGO staging and histological grading(P ＜ 0.05), but was not related with patients age, pelvic lymph node metastasis, depth of stroma infiltration, intravascular infiltration and survival rate(P ＞0.05). In the cases with FIGO staging Ⅱ and histological grading Ⅲ, the positive expression rate of HER3 was significantly higher than that in the cases without them (P ＜ 0. 05). Conclusion The over-expression of HER3 may lead to up regulation of tumor angiogenesis and cancer cell proliferation in SCC,and may promote progress of SCC.
