天然产物研究与开发
天然產物研究與開髮
천연산물연구여개발
NATURAL PRODUCT RESEARCH AND DEVELOPMENT
2009年
4期
559-562
,共4页
嗓属%长穗桑%抗氧化%Diels-Alder型加合物
嗓屬%長穗桑%抗氧化%Diels-Alder型加閤物
상속%장수상%항양화%Diels-Alder형가합물
Morus%Morus wittiorum%antioxidant%Diels-Alder type adducts
从长穗桑的茎皮中首次分离到9个Diels-Alder型加合物,通过NMR、MS等波谱分析手段分别鉴定为mulberrofuran K(1),mulberrofuran G(2),guangsangon L(3),kuwanon J(4),kuwanon X(5),guangsangon G(6),guangsangon B(7),guangsangon D(8),kuwanon P(9).化合物1～9进行了抗氧化活性筛选.结果表明,在10~(-5)M浓度下,化合物1,2,5～7,9对Fe~(2+)-半胱氨酸诱导的肝微粒体脂质过氧化产生的丙二醛(malondialdehyde,MDA)有抑制作用(抑制率大于50%).
從長穗桑的莖皮中首次分離到9箇Diels-Alder型加閤物,通過NMR、MS等波譜分析手段分彆鑒定為mulberrofuran K(1),mulberrofuran G(2),guangsangon L(3),kuwanon J(4),kuwanon X(5),guangsangon G(6),guangsangon B(7),guangsangon D(8),kuwanon P(9).化閤物1～9進行瞭抗氧化活性篩選.結果錶明,在10~(-5)M濃度下,化閤物1,2,5～7,9對Fe~(2+)-半胱氨痠誘導的肝微粒體脂質過氧化產生的丙二醛(malondialdehyde,MDA)有抑製作用(抑製率大于50%).
종장수상적경피중수차분리도9개Diels-Alder형가합물,통과NMR、MS등파보분석수단분별감정위mulberrofuran K(1),mulberrofuran G(2),guangsangon L(3),kuwanon J(4),kuwanon X(5),guangsangon G(6),guangsangon B(7),guangsangon D(8),kuwanon P(9).화합물1～9진행료항양화활성사선.결과표명,재10~(-5)M농도하,화합물1,2,5～7,9대Fe~(2+)-반광안산유도적간미립체지질과양화산생적병이철(malondialdehyde,MDA)유억제작용(억제솔대우50%).
Nine Diels-Alder type adduets have been isolated from the stem bark of Morus wittiorura for the first time. And on the basis of spectral analysis such as NMR,MS etc. ,structures of the compounds were identified as mulberrofuran K(1) ,mul-berrofuran G(2),guangsangon L(3),kuwanon J(4) ,kuwanon X(5),guangsangon G(6),guangsangon B(7),guangsangon D (8), kuwanon P(9). The anti-oxidative activity of compounds 1-9 were assayed. As a result ,compounds 1,2,5-7,9 showed in-hibition to malondialdehyde(MDA) produced during mierosomal lipid peroxidation induced by ferrous-eysteine (the inhibitory ratios were more than 50%) at a concentration of 10~(-5) M.
