中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2010年
1期
28-32,36
,共6页
宋敏%谭鸿毅%谭志荣%刘畅%阳丽%向红%黄志军%张桂香%阳国平
宋敏%譚鴻毅%譚誌榮%劉暢%暘麗%嚮紅%黃誌軍%張桂香%暘國平
송민%담홍의%담지영%류창%양려%향홍%황지군%장계향%양국평
布洛芬%伪麻黄碱%氯苯那敏%药代动力学%高效液相色谱%高效液相色谱-串联质谱
佈洛芬%偽痳黃堿%氯苯那敏%藥代動力學%高效液相色譜%高效液相色譜-串聯質譜
포락분%위마황감%록분나민%약대동역학%고효액상색보%고효액상색보-천련질보
ibuprofen%pseudo ephedrine%chlorpheniramine%pharmaco-kinetics%HPLC%HPLC-MS-MS
目的 研究布洛伪麻那敏干混悬剂(抗感冒药)在健康成年志愿者体内的药代动力学.方法 3个单剂量组及1个多剂量组口服给药,用高效液相色谱.紫外检测法测定给药后不同时间布洛芬血药浓度,高效液相色谱-串联质谱法测定给药后不同时间伪麻黄碱和氯苯那敏血药浓度.用DAS Ver 2.0计算药代动力学参数并进行统计分析.结果 3组单剂量及连续口服布洛芬(单剂:200,400,600 mg;连续:200 mg)、伪麻黄碱(单剂:30,60,90 mg;连续:30 mg)及氯苯那敏(单剂:2,4,6 mg;连续2 mg)7天后的主要药代动力学参数(t_(max),C_(max),AUC_(0-t),AUC_(0-∞),t_(1/2)等)结果显示,布洛芬、伪麻黄碱和氯苯那敏血药浓度-时间曲线拟合结果均符合一室模型,体内过程均旱线性动力学特征.结论 连续多次给药,3组分都不存在药酶诱导或抑制现象.
目的 研究佈洛偽痳那敏榦混懸劑(抗感冒藥)在健康成年誌願者體內的藥代動力學.方法 3箇單劑量組及1箇多劑量組口服給藥,用高效液相色譜.紫外檢測法測定給藥後不同時間佈洛芬血藥濃度,高效液相色譜-串聯質譜法測定給藥後不同時間偽痳黃堿和氯苯那敏血藥濃度.用DAS Ver 2.0計算藥代動力學參數併進行統計分析.結果 3組單劑量及連續口服佈洛芬(單劑:200,400,600 mg;連續:200 mg)、偽痳黃堿(單劑:30,60,90 mg;連續:30 mg)及氯苯那敏(單劑:2,4,6 mg;連續2 mg)7天後的主要藥代動力學參數(t_(max),C_(max),AUC_(0-t),AUC_(0-∞),t_(1/2)等)結果顯示,佈洛芬、偽痳黃堿和氯苯那敏血藥濃度-時間麯線擬閤結果均符閤一室模型,體內過程均旱線性動力學特徵.結論 連續多次給藥,3組分都不存在藥酶誘導或抑製現象.
목적 연구포락위마나민간혼현제(항감모약)재건강성년지원자체내적약대동역학.방법 3개단제량조급1개다제량조구복급약,용고효액상색보.자외검측법측정급약후불동시간포락분혈약농도,고효액상색보-천련질보법측정급약후불동시간위마황감화록분나민혈약농도.용DAS Ver 2.0계산약대동역학삼수병진행통계분석.결과 3조단제량급련속구복포락분(단제:200,400,600 mg;련속:200 mg)、위마황감(단제:30,60,90 mg;련속:30 mg)급록분나민(단제:2,4,6 mg;련속2 mg)7천후적주요약대동역학삼수(t_(max),C_(max),AUC_(0-t),AUC_(0-∞),t_(1/2)등)결과현시,포락분、위마황감화록분나민혈약농도-시간곡선의합결과균부합일실모형,체내과정균한선성동역학특정.결론 련속다차급약,3조분도불존재약매유도혹억제현상.
Objective To study the pharmacokinetics profiles of ibupro-fen and pseudo ephedrine with chlorpheniramine suspension after single and multiple dosing in healthy volunteers.Methods Three single and one multiple oral doses of ibuprofen and pseudo ephedrine with chlorphe-niramine suspension were given to healthy volunteers respectively.Ibu-profen concentrations in plasma were determined by HPLC-UV method.Pseudo ephedrine and chlorpheniramine concentrations in plasma were determined by HPLC-MS-MS method.The pharmacokinetic parameters were obtained with statistical analysis by DAS Ver 2.0.Results The main pharmacokinetic parameters of 3 single doses(ibuprofen:200,400,600 mg pseudo ephedrine:30,60,90 mg;chlorpheniramine:2,4,6 mg)and multiple dose(ibuprofe,pseudo ephedrine and chlorphe-niramine 200,30,2 mg,respectively)shown that the concentration-time curves of ibuprofen,pseudo ephedrine and chlorpheniramine were described by one-compartment open model and physiological disposi-tions were assumed by linear kinetics characteristics.Conclusion In multiple dosing study,physiological dispositions of ibuprofen,pseudo e-phedrine and chlorpheniramine all existed no induction and inhibition of drug enzyme phenomenon.