CAJ | 학술논문

目的探讨甲氨蝶呤和地塞米松鞘内注射治疗系统性红斑狼疮(SLE)中枢神经系统损害的效果.方法对18例鞘内注射的SLE中枢神经系统损害患者治疗前后的临床表现、脑脊液、头颅CT或磁共振成像(MRI)进行对比分析,并与27例未行鞘内注射者的情况进行对照.结果 18例患者中1例死亡,其他患者病情均明显改善或完全缓解;脑脊液压力明显下降,蛋白水平降低,葡萄糖升高.结论甲氨蝶呤和地塞米松鞘内注射治疗SLE中枢神经系统损害有明显效果,能提高抢救成功率,副作用轻且少,值得临床推荐使用.
목적 탐토갑안접령화지새미송초내주사치료계통성홍반랑창(SLE)중추신경계통손해적효과.방법 대18례초내주사적SLE중추신경계통손해환자치료전후적림상표현、뇌척액、두로CT혹자공진성상(MRI)진행대비분석,병여27례미행초내주사자적정황진행대조.결과 18례환자중1례사망,기타환자병정균명현개선혹완전완해;뇌척액압력명현하강,단백수평강저,포도당승고.결론 갑안접령화지새미송초내주사치료SLE중추신경계통손해유명현효과,능제고창구성공솔,부작용경차소,치득림상추천사용.
Objective To evaluate the intrathecal injection of combining methotrexate (MTX) and dexamethasone (DXM) into lupus patients with central nervous involvement.Methods Eighteen cases of central nervous system involvement with systemic lupus erythmatosus (SLE) accepted intrathecal injection of MTX plus DMX．Data including cl inical manifestations,cerebrospinal fluid and skull CT or MRI before and after treatment were analyzed．Meanwhile．the mortalities between 18 cases treated with intrathecal injection and 27 cases received normal management without intrathecal injection were ompared．Results Intrathecal in jection of MTX plus DXM was given to 17 SLE-central nervous system(CNS)patients except lcases death．The symptoms and signs were remitted or relieved obviously including the decrease of pressure and protein and elevation of glucose in cerebrospinal fluid．Conclusions Without any severe side effects，intrathecal injection with MTX plus DXM yielded satisfactory effects on patients with SLE-CNS，particularly in those with focus manifestations．