CAJ | 학술논문

目的探讨BNP指标在充血性心力衰竭患者疗效评估中的敏感及稳定性.方法选取确诊为充血性心衰患者80例,分别测定每例患者治疗前、治疗后1周、1个月及3个月的NYHA心功能分级、BNP水平及左室射血分数(LVEF),对每例患者不同时段的疗效差别进行统计分析.结果在卡托普利联合美托洛尔方案治疗充血性心力衰竭的第1周、第1个月及第3个月血浆BNP水平的改变幅度(定义为疗效)与LVEF值的改变幅度(定义为疗效)的差别经统计学分析.结果无统计学意义(P>0.05);在慢性充血性心力衰竭药物治疗后的第1周,BNP与NYHA心功能分级的改变幅度(定义为疗效)差异具有统计学意义(P<0.05),而在治疗后的第1及第3个月时两指标改变幅度(定义为疗效)的差异经统计学分析.结果无统计学意义(P>0.05).结论动态测定BNP水平在充血性心力衰竭疗效的定量分析中具有较高的敏感及稳定性,是一种可用于充血性心力衰竭早期疗效评估的可靠工具.
목적 탐토BNP지표재충혈성심력쇠갈환자료효평고중적민감급은정성.방법 선취학진위충혈성심쇠환자80례,분별측정매례환자치료전、치료후1주、1개월급3개월적NYHA심공능분급、BNP수평급좌실사혈분수(LVEF),대매례환자불동시단적료효차별진행통계분석.결과 재잡탁보리연합미탁락이방안치료충혈성심력쇠갈적제1주、제1개월급제3개월혈장BNP수평적개변폭도(정의위료효)여LVEF치적개변폭도(정의위료효)적차별경통계학분석.결과 무통계학의의(P>0.05);재만성충혈성심력쇠갈약물치료후적제1주,BNP여NYHA심공능분급적개변폭도(정의위료효)차이구유통계학의의(P<0.05),이재치료후적제1급제3개월시량지표개변폭도(정의위료효)적차이경통계학분석.결과 무통계학의의(P>0.05).결론동태측정BNP수평재충혈성심력쇠갈료효적정량분석중구유교고적민감급은정성,시일충가용우충혈성심력쇠갈조기료효평고적가고공구.
Objective To explore the sensitivity and constancy of BNP in evaluating the therapeutic effect of congestive heart failure.Methods 80 patients made a definite diagnosis of congestive heart failure were selected and whose cardiac functional grading of NYHA,BNP and left ventricular ejection fraction (LVEF) were determined respectively pre-treatment,one week,one month and three months after-treatment.Statistical analysis on the difference of therapeutic effect was performed for each case.Results No statistical difference was found between the amplitude of BNP and LVEF in one week and on one month, three months pro-treatment by the scheme of captopril combining with metoprolol (P>0.05 ).But between the BNP and the cardiac functional grading,statistica difference was found in the fitst week pro-treament(P<0.05),when on one month and three months after treatment the statistical difference still not found(P>0.05).Conclusion BNP dynamic measuring had the hige sensitivity and constancy in quantitatively analysing the therapeutic effect of congestive heart failure which could be used as a reliable tool for evaluating the therapeutic effect of congestive heart failure.