CAJ | 학술논문

目的评价Cockcroft-Gauh(CG)方程及肾脏疾病膳食改良试验(MDRD)方程计算的肾小球滤过率(GFR)在慢性肾小球肾炎患者的适用性.方法选择2005年1月至2007年12月在中山大学附属第三医院肾内科就诊的慢性肾小球肾炎患者143例,用CG方程、MDRD1方程和简化MDRD方程,分别计算GFR值与99Tcm-DTPA检测的GFR(sGFR)进行比较.结果 Bland-Altman分析显示CG方程估计的GFR和sGFR的一致性较好,但所有各方程估计的GFR和sGFR的一致性限度均超过事先规定的专业界值.线性回归结果显示,CG方程估测的GFR与x轴的斜率较其他方程更接近0.从总体以及慢性肾脏病(CKD)的不同分期分析,CG方程较其他方程有较小的偏差和更优的准确性.结论对于慢性肾小球肾炎患者肾功能的评估,当血肌酐的测定方法为酶法时,CG方程优于MDRD1方程和简化MDRD方程.
목적 평개Cockcroft-Gauh(CG)방정급신장질병선식개량시험(MDRD)방정계산적신소구려과솔(GFR)재만성신소구신염환자적괄용성.방법 선택2005년1월지2007년12월재중산대학부속제삼의원신내과취진적만성신소구신염환자143례,용CG방정、MDRD1방정화간화MDRD방정,분별계산GFR치여99Tcm-DTPA검측적GFR(sGFR)진행비교.결과 Bland-Altman분석현시CG방정고계적GFR화sGFR적일치성교호,단소유각방정고계적GFR화sGFR적일치성한도균초과사선규정적전업계치.선성회귀결과 현시,CG방정고측적GFR여x축적사솔교기타방정경접근0.종총체이급만성신장병(CKD)적불동분기분석,CG방정교기타방정유교소적편차화경우적준학성.결론대우만성신소구신염환자신공능적평고,당혈기항적측정방법 위매법시,CG방정우우MDRD1방정화간화MDRD방정.
Objective To evaluate the applicability of glomerular filtration rate (GFR) caJcuated by Cock-croft-Gault equation, MDRD1 equation and abbreviated MDRD equation in the chronic glomerulonephritis. Methods 143 chronic kidney disease(CKD) patients diagnosed in our hospital from January 2005 to December 2007 were investigated. Glomerular filtration rate(GFR) was estimated with Cockcroft-Gault equation, MDRD1 equation and ab-breviated MDRD equation. The accuracy of estimated GFRs was compared with 99Tcm-DTPA-GFR in chronic glomer-ulonephritis patients. Results Bland-Altman analysis demonstrated that Cockcroft-Gault equation was more consist-ent with GFR and sGFR than the other equations. Linear regression analysis showed that the slopes of Cockcroft-Gault equation were closer to the identical line,with a smaller bias and higher accuracy . When compared, the bias as well as accuracy of estimated GFRs with sGFR in different stages of CKD,Cockcroft-Gault equation showed good results. Condusion When plasma creatinine is checked with enzymatic method, Cockcroft-Gault equation is more appropriate than MDRD1 equation and abbreviated MDRD equation for estimating renal function in chronic glomeru-lonephritis patients.